VUF 8430 dihydrobromideA potent histamine H4 receptor full agonist

VUF 8430 dihydrobromide (CAS 100130-32-3)

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Application: A potent histamine H4 receptor full agonist
CAS Number: 100130-32-3
Molecular Weight: 323.05
Molecular Formula: C4H11N5S•2HBr
* Refer to Certificate of Analysis for lot specific data (including water content).
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VUF 8430 dihydrobromide is a potent histamine H4 receptor full agonist (pEC50 = 7.3), high affinity (pKi = 7.5). VUF 8430 dihydrobromide displays moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors.


References

1. Sterk, G.J., et al. 1986. Agents Actions. 18: 137-140.
2. Lim, H.D., et al. 2006. J. Med. Chem. 49: 6650-6651.
3. Lim, H.D., et al. 2008. J. Pharmacol. Exp. Ther. 327: 88-96.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Boiling Point :
348.8° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UM6960000
MDL Number :
MFCD01694605
SMILES :
Br.Br.NC(=N)NCCSC(=N)N

Download SDS (MSDS)

Certificate of Analysis

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