VU0155069A potent and specific inhibitor of phospholipase D1

VU0155069 (CAS 1130067-06-9)

VU0155069 | CAS 1130067-06-9 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_10, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_224371, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 81ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: N-[2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-naphthalenecarboxamide
Application: A potent and specific inhibitor of phospholipase D1
CAS Number: 1130067-06-9
Purity: ≥95%
Molecular Weight: 462.98
Molecular Formula: C26H27ClN4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

VU0155069 is a potent and specific inhibitor of PC-PLD1 (phospholipase D1). VU0155069 significantly decreases invasive migration in breast cancer cell lines (MDA-231, 4T1 and PMT). VU0155069 is an inhibitor of PC-PLD2.


References

1 Scott, S.A., et al. 2009. Nat. Chem. Bio. 5: 108-117. PMID: 19136975

Physical State :
Solid
Solubility :
Soluble in 1:4 DMF:PBS(pH 7.2) (~0.2 mg/ml), DMF (~25 mg/ml), DMSO (>25 mg/ml), and ethanol (>25 mg/ml).
Storage :
Store at -20° C
Density :
1.29 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
Optical Activity :
α20/D +81.2°, c = 1 in methanol
IC50 :
PC-PLD1: IC50 = 11 nM (Calu-1 cells); PC-PLD1: IC50 = 46 nM (in vitro); PC-PLD2: IC50 = 0.93 µM (in vitro); PC-PLD2: IC50 = 1.8 µM (HEK293-gfpPLD2 cells)
pK Values :
pKa: 11.11 (Predicted), pKb: 8.18 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56972237
MDL Number :
MFCD23160355
SMILES :
C[C@@H](CN1CCC(CC1)N2C3=C(C=C(C=C3)Cl)NC2=O)NC(=O)C4=CC5=CC=CC=C5C=C4.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

VU0155069  Product Citations

See how others have used VU0155069. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 29571767  Conde, MA. et al. 2018. Biochim. Biophys. Acta. 1863: 639-650.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 60ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from VU0155069 is a strong inhibitor of PC VU0155069 is a strong inhibitor of PC-PLD1/2 (phospholipase D1/D2) shown to reduce invasive migration of breast cancer cell lines and its use is cited in various publications. -SCBT Publication Review
Date published: 2015-01-03
  • y_2019, m_11, d_10, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_224371, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 38ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.