VU 590 dihydrochlorideAn inhibitor of the renal, outer medullary potassium channel, KIR7.1

VU 590 dihydrochloride (CAS 313505-85-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 68ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
Application: An inhibitor of the renal, outer medullary potassium channel, KIR7.1
CAS Number: 313505-85-0
Purity: ≥97%
Molecular Weight: 561.46 (anhydrous)
Molecular Formula: C24H32N4O72HCl•xH2O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

VU 590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (ROMK, KIR1.1) while also able to inhibit the inward rectifying potassium channel KIR7.1. This comppound is also reported to not display an effect towards KIR2.1 or KIR4.1 and additionally acts as an intracellular ROMK channel pore blocker.


References

1. Lewis, L.M., et al. 2009. Mol. Pharmacol. 76: 1094-1103. PMID: 19706730

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Desiccate at -20° C
IC50 :
Kir1.1, ROMK: IC50 = 294 nM (renal)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1COCCN(CCOCCOCCN1CC2=CC=C(C=C2)[N+](=O)[O-])CC3=CC=C(C=C3)[N+](=O)[O-].Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 74ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 30ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.