Voglibose is orally active Maltase-glucoamylase (α-glucosidase) inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). It increases glucagon-like peptide 1 (GLP-1) secretion and also decreases food consumption in ob/ob mice. Voglibose reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Additionally, voglibose exhibits antidiabetic and antiobesity activity in vivo.
Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S. Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559. Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669.
Soluble to 100 mM in Water and to 75 mM in DMSO
Desiccate at -20° C
~601.9° C at 760 mmHg (Predicted)
~1.6 g/cm3 (Predicted)
n20D 1.64 (Predicted)
α20/D +21.8°, c = 1 in water; α20/D +46.5°±1.5°, c = 1 in 0.1mol/l HCl
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What is the appearance of the compound?
Asked by: two2igm05
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Do et alDo et al. (PubMed ID 24388987) found that voglibose significantly reduced body weight, fat mass and energy intakes in high fat fed mic via modulation of hypothalamic expressions of leptin receptors and appetite related genes. -SCBT Publication Review
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