VogliboseCAS: 83480-29-9
MF: C10H21NO7
MW: 267.28
An α-glucosidase inhibitor that increases glucagon-like peptide 1 secretion.

Voglibose (CAS 83480-29-9)

Voglibose | CAS 83480-29-9 is rated 5.0 out of 5 by 1.
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Synonym: Basen; Glustat; Vocarb
Application: An α-glucosidase inhibitor that increases glucagon-like peptide 1 secretion
CAS Number: 83480-29-9
Purity: ≥99%
Molecular Weight: 267.28
Molecular Formula: C10H21NO7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Voglibose is orally active Maltase-glucoamylase (α-glucosidase) inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). It increases glucagon-like peptide 1 (GLP-1) secretion and also decreases food consumption in ob/ob mice. Voglibose reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Additionally, voglibose exhibits antidiabetic and antiobesity activity in vivo.


References

Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S. Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559. Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble to 100 mM in Water and to 75 mM in DMSO
Storage :
Desiccate at -20° C
Melting Point :
163-168° C
Boiling Point :
~601.9° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
Optical Activity :
α20/D +21.8°, c = 1 in water; α20/D +46.5°±1.5°, c = 1 in 0.1mol/l HCl
IC50 :
Sucrase-isomaltase: IC50 = 70 nM (rat); LYAG: IC50 = 70 nM (human); Acidic α-glucosidase: IC50 = 110 nM (rat); α-glucosidase: IC50 = 23.4 µM; Glycogen debranching enzyme: IC50 = 70 µM (Oryctolagus cuniculus)
pK Values :
pKa: 13.26 (Predicted), pKb: 6.84 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NM7524600
PubChem CID :
444020
Merck Index :
14: 10029
MDL Number :
MFCD00865496
Beilstein Registry :
5430708

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Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The chemical, sc-204384, is provided as a white to off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-12
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Rated 5 out of 5 by from Do et al Do et al. (PubMed ID 24388987) found that voglibose significantly reduced body weight, fat mass and energy intakes in high fat fed mic via modulation of hypothalamic expressions of leptin receptors and appetite related genes. -SCBT Publication Review
Date published: 2015-02-22
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