Vitamin D2A cell differentiation inducer and DNA polymerase inhibitor

Vitamin D2 (CAS 50-14-6)

Vitamin D2 | CAS 50-14-6 is rated 5.0 out of 5 by 1.
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Synonym: Calciferol; Ergocalciferol; Viostero
Application: A cell differentiation inducer and DNA polymerase inhibitor
CAS Number: 50-14-6
Purity: ≥97%
Molecular Weight: 396.65
Molecular Formula: C28H44O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Vitamin D2 is the synthetic form of Vitamin D and has been shown to aid in the absorption of calcium and phosphorus. Vitamin D2 has a strong inhibitory effect against bladder tumor promotion by sodium saccharin and induces cell differentiation in leukemia cells. Vitamin D2 has also been shown to be an inhibitor of DNA polymerase.


References

1. Yen, A., et al., 1991. 1,25-Dihydroxy vitamin D2 induces leukemia cell differentiation. In vitro cellular & developmental biology : journal of the Tissue Culture Association. 27A(7): 518-20. PMID: 1653778
2. Yazawa, Y., et al., 2000. Antitumor promoting effect of an active component of Polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin A. Biological & pharmaceutical bulletin. 23(11): 1298-302. PMID: 11085355

Physical State :
Solid
Solubility :
Soluble in ethanol (80 mg/ml at 25° C), water (<1 mg/ml at 25° C), methanol, DMF (~20 mg/ml), and DMSO (20 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
114-118° C (lit.)
Density :
1.03 g/cm3 at 20° C
Refractive Index :
n25D 1.51
Optical Activity :
α25/D 103°±3°, c = 1.5 in ethanol; α20/D 110°, c = 1.5 in ethanol; α20/D 105°±2°, c = 4 in ethanol; α20/D 101.5°, c = 1.25 in ethanol; α25/D 82.6°, c = 3 in acetone
IC50 :
Hepatitis C virus: EC5050 = 3.8 µM (Hepatitis C virus); Mammalian DNA polymerase A: IC50 = 123 mM
pK Values :
pKa: 18.38 (Predicted), pKb: -1.3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
KE1050000
PubChem CID :
5280793
Merck Index :
14: 10018
MDL Number :
MFCD00166988
EC Number :
200-014-9
Beilstein Registry :
1916682
SMILES :
C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C

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Certificate of Analysis

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Vitamin D2  Product Citations

See how others have used Vitamin D2. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28179397  Choi, B. et al. 2017. Circulation. 135: 1935-1950.

Citations 1 to 1 of 1 total

I would like to know that is it possible to produce Vitamin D2 (Ergocalciferol) in 50,000 IU (International Units). If yes, then what will be its cost for bulk production.

Asked by: Qazi Mustafa
Thank you for your question. We currently do provide Vitamin D2 (CAS 50-14-6): sc-205988 in a 1g and 5 g quantity, and the list price is on our website. Please note that this is a research-grade chemical, and it is not intended for Diagnostic or Therapeutic use.
Answered by: Technical Support
Date published: 2017-07-18
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Rated 5 out of 5 by from Bennett Bennett, L. et al. (PubMed 24204618) reported that Vitamin D2-enriched button mushroom (Agaricus bisporus) improves memory in both wild type and APPswe/PS1dE9 transgenic mice. -SCBT Publication Review
Date published: 2015-06-10
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