Vitamin D2, 1a-Hydroxy-An analog of vitamin D2 and is a VDR activator

Vitamin D2, 1a-Hydroxy- (CAS 54573-75-0)

Vitamin D2, 1a-Hydroxy- | CAS 54573-75-0 is rated 5.0 out of 5 by 1.
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Synonym: Doxercalciferol
Application: An analog of vitamin D2 and is a VDR activator
CAS Number: 54573-75-0
Purity: ≥98%
Molecular Weight: 412.7
Molecular Formula: C28H44O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Vitamin D2, 1a-Hydroxy- is a vitamin D2 analog which acts as a VDR (vitamin D receptor) activator. Vitamin D2, 1a-Hydroxy- is metabolized to the natural active dihydroxylated metabolite of vitamin D2, 1α,25-dihydroxyvitamin D2.


References

1. Knutson, J.C., et al. 1995. Endocrinology. 136: 4749-4753. PMID: 7588202
2. Coburn, J.W., et al. 1996. Nephrol. Dial. Transplant. 11: 153-157. PMID: 8840332

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), ethanol (50 mM), ethanol:PBS(pH 7.2) 1:2 (~0.3 mg/ml), and DMF (~20 mg/ml).
Storage :
Store at -20° C
Melting Point :
194.70° C (Predicted)
Boiling Point :
538.68° C at 760 mmHg (Predicted)
Density :
1.02 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VS2950000
PubChem CID :
5281107
Merck Index :
14: 3436
MDL Number :
MFCD00871065
Beilstein Registry :
4716774
SMILES :
CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wang Wang, XX. et al. (PubMed 21209008) reported that vitamin D receptor agonist Doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism. -SCBT Publication Review
Date published: 2015-04-24
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