VindolineA monomeric vinca-alkaloid

Vindoline (CAS 2182-14-1)

Vindoline | CAS 2182-14-1 is rated 5.0 out of 5 by 1.
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Synonym: Methyl 4-(acetyloxy)-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
Application: A monomeric vinca-alkaloid
CAS Number: 2182-14-1
Molecular Weight: 456.54
Molecular Formula: C25H32N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Vindoline is a monomeric vinca-alkaloid, forms lower portion of the lead anti-tumor agents, vinblastine and vincristine. Vindoline exhibits reciprocal cross-resistance to vincristine and vinblastine.


References

Fahy J. Curr Pharm Des 7:1181-1197 (2001) Inaba M, Nagashima K. Ipn J Cancer res 77:197-204 (1986).

Physical State :
Solid
Solubility :
Soluble in water (30 mg/ml), 100%ethanol, methanol, chloroform, and DMSO (~3 mg/ml).
Storage :
Store at -20° C
Melting Point :
158-161° C
Boiling Point :
569.83° C at 760 mmHg (Predicted)
Density :
1.33 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α20/D -65°±3°, c = 1.5 in methanol; α20/D -59.2°, c = 0.5 in methanol
pK Values :
pKa: 11.4 (Predicted), pKb: 5.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CJ0120000
PubChem CID :
260535
Merck Index :
14: 9988
EC Number :
218-558-0
SMILES :
CC[C@@]12C=CCN3[C@@H]1[C@]4(CC3)[C@H]([C@]([C@@H]2OC(=O)C)(C(=O)OC)O)N(C5=C4C=CC(=C5)OC)C

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Certificate of Analysis

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What is the purity of your vindoline?

Asked by: Pooja Singh
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2018-12-07
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Rated 5 out of 5 by from Yao et al Yao et al. (PubMed ID 24012527) found that vindoline enhanced glucose-stimulated insulin secretion in both glucose- and dose-dependent manners via Kv2.1 inhibition that reduced voltage-dependent outward potassium currents. -SCBT Publication Review
Date published: 2015-03-22
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