VidarabineA neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes

Vidarabine (CAS 5536-17-4)

Vidarabine | CAS 5536-17-4 is rated 5.0 out of 5 by 1.
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Synonym: Arabinosyladenine; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine
Application: A neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes
CAS Number: 5536-17-4
Purity: ≥99%
Molecular Weight: 267.24
Molecular Formula: C10H13N5O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Vidarabine is a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes. Vidarabine is an inhibitor of A cyclase and DNA Polymerase.


References

Honma Y, Nitsu N. Leuk Lymphoma. 399:57-66 (2000). Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247.

Physical State :
Solid
Solubility :
Soluble in DMF (10 mg/ml), 0.5 M HCl (50 mg/ml), DMSO (53 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and water (3 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
260° C
Boiling Point :
676.27° C at 760 mmHg (Predicted)
Density :
~2.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.91 (Predicted)
Optical Activity :
α20/D -60.5°±4.5° in DMF
IC50 :
PRK cell line: IC50 = 0.4 ug.mL-1; Moloney murine leukemia virus: IC50 = 1 ug.mL-1; herpesvirus 1: IC50 = 5.6 ug.mL-1 (human); CCRF-HSB-2: IC50 = 12.9 ug.mL-1 (human); HL-60: IC50 = 20.9 ug.mL-1 (human)
Ki Data :
Adenosylhomocysteinase : Ki= 30 µM (rat)
pK Values :
pKa: 13.11 (Predicted), pKb: 3.82 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU6200000
PubChem CID :
21704
Merck Index :
14: 9976
MDL Number :
MFCD00065471
EC Number :
226-893-9
Beilstein Registry :
624881
SMILES :
C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O

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Certificate of Analysis

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Vidarabine  Product Citations

See how others have used Vidarabine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26416623  Lehouritis, P. et al. 2015. Sci Rep. 5: 14554.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Sharma S; et al Sharma S; et al. (PubMed ID: 26081925) utilized Vidarabine, to study the kinase inhibitory action of purines as potential cancer therapies. -SCBT Publication Review
Date published: 2015-03-01
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