VerruculogenA neurotoxin that inhibits the M phase of the mammalian cell cycle

Verruculogen (CAS 12771-72-1)

Verruculogen | CAS 12771-72-1 is rated 5.0 out of 5 by 1.
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Synonym: TR 1 toxin
Application: A neurotoxin that inhibits the M phase of the mammalian cell cycle
CAS Number: 12771-72-1
Molecular Weight: 511.57
Molecular Formula: C27H33N3O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Verruculogen is a neurotoxin that inhibits the M phase of the mammalian cell cycle. Inhibits Ca2+-activated K+ channels. Decreases GABA levels in CNS.


References

Tremorgenic indole alkaloids potently inhibit smooth muscle high- conductance calcium-activated potassium channels: H.H. Knaus, et al.; Biochemistry 33, 5819 (1994) Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico- chemical properties and structures: C.B. Cui, et al.; J. Antibiot. (Tokyo) 49, 534 (1996) Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres.: I. Kosalec, et al.; Acta Pharm. 55, 357 (2005)

Physical State :
Solid
Solubility :
Soluble in ethyl acetate, DMSO, 100% ethanol, and methanol.
Storage :
Store at 4° C
Boiling Point :
738.36° C at 760 mmHg (Predicted)
Density :
1.49 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
JH4920000
PubChem CID :
13887805
SMILES :
CC(=C[C@@H]1N2C3=C(C=CC(=C3)OC)C4=C2[C@H](CC(OO1)(C)C)N5C(=O)[C@@H]6CCCN6C(=O)[C@@]5([C@H]4O)O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Bradford et al Bradford et al. (PubMed ID 1977902) showed verruculogen caused a significant increase in the miniature-end-plate potential frequency at the locust neuromuscular junction. -SCBT Publication Review
Date published: 2015-01-06
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