VeratridineA voltage dependent Na+ channel opening agent

Veratridine (CAS 71-62-5)

Veratridine | CAS 71-62-5 is rated 5.0 out of 5 by 1.
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Application: A voltage dependent Na+ channel opening agent
CAS Number: 71-62-5
Purity: ≥98%
Molecular Weight: 673.8
Molecular Formula: C36H51NO11
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Veratridine is an agent that opens voltage dependent Na+ channels, blocks Na+ channel activation, and induces Ca2+ influx. The compound has been observed to be an alkaloid neurotoxin used to amplify sodium permeability. Studies report that Veratridine can trigger exocytosis and induce Ca2+ oscillations. Furthermore, Veratridine has been shown to effect the mitochondrial respiratory chain complexes, induce release of noradrenaline, and increase superoxide anion production.


References

1. McKinney, L.C., et al. 1986. Anal. Biochem. 153: 33-38. PMID: 3963380
2. Sutro, J.B. 1986. J. Gen. Physiol. 87: 1-24. PMID: 2419478
3. Leibowitz, M.D., et al. 1986. J. Gen. Physiol. 87: 25-46. PMID: 2419480
4. Rando, T.A. 1989. J. Gen. Physiol. 93: 43-65. PMID: 2536798
5. Maroto, R., et al. 1994. Eur. J. Pharmacol. 270: 331-339. PMID: 7805782
6. Plattner, H., et al. 1994. J. Membr. Biol. 142: 229-240. PMID: 7884815
7. Meder, W., et al. 1997. Naunyn Schmiedebergs Arch. Pharmacol. 356: 797-805. PMID: 9453466
8. Jordán, J., et al. 2000. Br. J. Pharmacol. 130: 1496-1504. PMID: 10928950
9. Koike, T. and Ninomiya, T. 2000. Neuroreport. 11: 151-155. PMID: 10683848
10. Sumiya, Y., et al. 2001. Neurochem. Int. 39: 59-63. PMID: 11311450
11. Silva Freitas, E.M., et al. 2006. Toxicon. 47: 780-787. PMID: 16626771

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), ether (slightly insoluble), and 1 M HCl (50 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
180° C
Boiling Point :
~814.5° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YX5600000
PubChem CID :
6280
Merck Index :
9954
MDL Number :
MFCD00082515
EC Number :
200-758-4
Beilstein Registry :
78875
SMILES :
C[C@H]1CC[C@H]2[C@@]([C@]3([C@H](C[C@]4([C@@H]5CC[C@H]6[C@]7([C@]5(C[C@]4([C@@H]3CN2C1)O)O[C@@]6([C@H](CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O

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Rated 5 out of 5 by from Silva Freitas et al Silva Freitas et al. (PubMed ID 16626771) found that veratridine led to a concentration-dependent attentuation in respiration, respiratory control and ADP/O rations in rat skeletal muscle mitochondria. -SCBT Publication Review
Date published: 2015-03-16
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