Veratramine, HClCAS: 1258005-82-1
MF: C27H39NO2•HCl
MW: 446.07
An inactive control for cyclopamine, cyclopamine-KAAD, and jervine.

Veratramine, HCl (CAS 1258005-82-1)

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Application: An inactive control for cyclopamine, cyclopamine-KAAD, and jervine
CAS Number: 1258005-82-1
Molecular Weight: 446.07
Molecular Formula: C27H39NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).

Veratramine Hydrochloride is a cell-permeable steroidal alkaloid that is structurally related to cyclopamine (sc-200929), cyclopamine-KAAD (sc-221448), and jervine (sc-200934). It can be used as an inactive control for these compounds in sonic hedgehog (Shh) signaling studies.


References

1. Incardona, J P., et al., 1998. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development (Cambridge, England). 125(18): 3553-62. PMID: 9716521
2. Zeng, Li., et al., 2002. Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes & development. 16(15): 1990-2005. PMID: 12154128

Physical State :
Solid
Solubility :
DMSO or 5% acetic acid
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24847666
SMILES :
C[[email protected]]1CC([[email protected]@H](NC1)[[email protected]@H](C)C2=C(C3=C(C=C2)[[email protected]@H]4CC=C5CC(CC[[email protected]@]5([[email protected]]4C3)C)O)C)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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