Venlafaxine HydrochlorideAn inhibitor of ST and SLC6A2

Venlafaxine Hydrochloride (CAS 99300-78-4)

Venlafaxine Hydrochloride | CAS 99300-78-4 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of ST and SLC6A2
CAS Number: 99300-78-4
Purity: 98%
Molecular Weight: 313.9
Molecular Formula: C17H27NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Venlafaxine Hydrochloride is a dual ST and SLC6A2 (serotonin and noradrenalin re-uptake) inhibitor that displays ~ 30-fold higher affinity for ST (SERT) (Ki = 82 nm) than SLC6A2 (NET) (Ki = 2480 nM).


References

1. Holdcroft, C. 1994. Nurse Pract. 19: 21. PMID: 7816367
2. Holliday, S.M. and Benfield, P. 1995. Drugs. 49: 280-294. PMID: 7729333
3. Bymaster, F.P., et al. 2001. Neuropsychopharmacology. 25: 871-880. PMID: 11750180
4. Stahl, S.M., et al. 2005. CNS Spectr. 10: 732-747. PMID: 16142213
5. Shams, M.E., et al. 2006. J Clin Pharm Ther. 31: 493-502. PMID: 16958828
6. Blier, P., et al. 2007. Int. J. Neuropsychopharmacol. 10: 41-50. PMID: 16690005
7. Berrocoso, E. and Mico, J.A. 2007. J. Pharmacol. Exp. Ther. 322: 101-107. PMID: 17431134

Physical State :
Solid
Solubility :
Soluble in water (>25 mg/ml), and DMSO (50 mM).
Storage :
Store at room temperature
Melting Point :
217° C (lit.)
Ki Data :
SERT: Ki= 82 nM; NET: Ki= 2480 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GV8872760
PubChem CID :
62923
Merck Index :
14: 9946
MDL Number :
MFCD03658865
SMILES :
CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Venlafaxine Hydrochloride  Product Citations

See how others have used Venlafaxine Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27959497  Krout, D. et al. 2017. ACS Chem Neurosci. 8: 1011-1018.

PMID: # 25047821  Ribeiro, AR. et al. 2014. Journal of chromatography. A. 1363: 226-35.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Hussain SA; et al Hussain SA; et al. (PubMed ID: 26401414) determined that Venlafaxine Hydrochloride is increased in the kidney when exposed to Gingko bilob extract. -SCBT Publication Review
Date published: 2015-01-25
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