Valproic Acid-d6 CAS: 87745-18-4
MF: C8H10D6O2
MW: 150.25
A deuterium-labelled form of Valproic Acid.

Valproic Acid-d6 (CAS 87745-18-4)

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Alternate Names: 2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid; 2-Propylvaleric Acid-d6; 4-Heptanecarboxylic Acid-d6
Application: Valproic Acid-d6 is a deuterium-labelled form of Valproic Acid
CAS Number: 87745-18-4
Purity: ≥98%
Molecular Weight: 150.25
Molecular Formula: C8H10D6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Valproic Acid-d6 is a deuterium-labelled form of Valproic Acid. Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Metabolites of Valproic Acid are also available as:
Valproic Acid (sc-213144)
Valproic Acid, Sodium Salt (sc-202378)
3-Hydroxy Valproic Acid (sc-209599)
3-Keto Valproic Acid Sodium Salt (sc-216476)
4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870)
rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266)
Valproic Acid β-D-Glucuronide Allyl Ester (sc-220360)
Valproic Acid β-D-Glucuronide (sc-213145)

Labelled forms of Valproic Acid are available as:
Valproic Acid-d6 β-D-Glucuronide (sc-220361)
rac 5-Hydroxy Valproic Acid-d7 Sodium Salt (sc-219789)


References

1. Della Paschoa, O.E., et al. 1998. Br. J. Pharmacol. 125: 1610-1616. PMID: 9884091
2. Tunnicliff, G. 1999. J. Physiol. Pharmacol. 50: 347-365. PMID: 10574466
3. Göttlicher, M., et al. 2001. EMBO J. 20: 6969-6978. PMID: 11742974
4. Phiel, C.J., et al. 2001. J. Biol. Chem. 276: 36734-36741. PMID: 11473107
5. Gökçe, S., et al. 2010. J. Child Neurol. 25: 909-911. PMID: 20388938

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in Alcohol and Water
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
[2H]C([2H])([2H])CCC(CCC([2H])([2H])[2H])C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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