Valinomycin is a cyclododecadepsipeptide potassium-selective ionophore. It is an antibiotic that was originially isolated from various strains of Streptomyces. The hydrophilic interior is the right size to accommodate the potassium ion, but not other ions, while the hydrophobic exterior allows the complex to pass through the lipid bilayer. Valinomycin induces apoptosis in several cell types, including CHO cells, by stimulating potassium efflux. Apoptotic events produced by valinomycin include phosphatidylserine membrane translocation, caspase-3 activation, and mitochondrial membrane depolarization. Due to the ion-selective nature of valinomycin, it is used in ion-selective electrodes.
1. Marques-Santos, L.F., et al. 2006. Cell Biol. Int. 30: 197-204. PMID: 16376584 2. Abdalah, R., et al. 2006. Neurosci. Lett. 405: 68-73. PMID: 16857314 3. Yamasaki, M., et al. 2009. J. Parasitol. 95: 1532-1538. PMID: 20929429 4. Kroteń, M.A., et al. 2010. Pol. J. Microbiol. 59: 3-10. PMID: 20568524
Soluble in ethanol (50 mg/ml), DMSO (≥10 mg/ml), petroleum ether, ether, benzene, chloroform, glacial acetic, butyl acetate, and methanol (5 mg/ml). Insoluble in water.
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Pei Y;et alPei Y;et al. (PubMed ID:26254731) confirmed that Valinomycin has cytotoxic effects to iPSC-derived neural stem cells (NSC), neurons, and astrocytes at 1, 10, and 100 M. -SCBT Publication Review
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