ValinomycinCAS: 2001-95-8
MF: C54H90N6O18
MW: 1111.4
A potassium ionophore shown to induce cell death.

Valinomycin (CAS 2001-95-8)

Valinomycin | CAS 2001-95-8 is rated 5.0 out of 5 by 1.
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Synonym: Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
Application: A potassium ionophore shown to induce cell death
CAS Number: 2001-95-8
Purity: >95%
Molecular Weight: 1111.4
Molecular Formula: C54H90N6O18
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Valinomycin is a cyclododecadepsipeptide potassium-selective ionophore. It is an antibiotic that was originially isolated from various strains of Streptomyces. The hydrophilic interior is the right size to accommodate the potassium ion, but not other ions, while the hydrophobic exterior allows the complex to pass through the lipid bilayer. Valinomycin induces apoptosis in several cell types, including CHO cells, by stimulating potassium efflux. Apoptotic events produced by valinomycin include phosphatidylserine membrane translocation, caspase-3 activation, and mitochondrial membrane depolarization. Due to the ion-selective nature of valinomycin, it is used in ion-selective electrodes.


References

1. Marques-Santos, L.F., et al. 2006. Cell Biol. Int. 30: 197-204. PMID: 16376584
2. Abdalah, R., et al. 2006. Neurosci. Lett. 405: 68-73. PMID: 16857314
3. Yamasaki, M., et al. 2009. J. Parasitol. 95: 1532-1538. PMID: 20929429
4. Kroteń, M.A., et al. 2010. Pol. J. Microbiol. 59: 3-10. PMID: 20568524

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mg/ml), DMSO (≥10 mg/ml), petroleum ether, ether, benzene, chloroform, glacial acetic, butyl acetate, and methanol (5 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
186-187° C
Boiling Point :
1321.60° C at 760 mmHg
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.45
Optical Activity :
α20/D +30.9°, c = 1.6 in benzene
IC50 :
endothelin-induced vasoconstriction : IC50 = 0.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YV9468000
PubChem CID :
5649
Merck Index :
14: 9910
MDL Number :
MFCD00005114
EC Number :
217-896-6
Beilstein Registry :
78657
SMILES :
CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C

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Valinomycin  Product Citations

See how others have used Valinomycin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30746686  2019. J. Cell. Physiol.

PMID: # 25308643  Vergara-Salinas, JR. et al. 2015. Food chemistry. 171: 62-9.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Pei Y;et al Pei Y;et al. (PubMed ID:26254731) confirmed that Valinomycin has cytotoxic effects to iPSC-derived neural stem cells (NSC), neurons, and astrocytes at 1, 10, and 100 M. -SCBT Publication Review
Date published: 2015-06-15
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