Molecular structure of UVI 3003, CAS Number: 847239-17-2
UVI 3003 (CAS 847239-17-2)
See product citations (5)
Alternate Names:
3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
Application:
UVI 3003 is a RXR antagonist which demonstrates a high RXR binding affinity
CAS Number:
847239-17-2
Purity:
≥98%
Molecular Weight:
436.58
Molecular Formula:
C28H36O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UVI 3003 is a chemical stabilizer integral to enhancing the durability of polymers exposed to ultraviolet light, critical in materials science research. It is extensively studied for its role in the absorption and dissipation of UV radiation, preventing the photodegradation of plastics used in various outdoor applications such as vehicle components and packaging. The interaction of UVI 3003 with polymer matrices is key to understanding its stabilizing mechanisms, which is vital for developing advanced materials with improved longevity and resistance to environmental factors. Investigations into the compatibility of UVI 3003 with diverse polymers and its impact on their properties are essential for optimizing formulations and achieving desired performance characteristics in UV-sensitive products.
UVI 3003 (CAS 847239-17-2) References
- Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRalpha LBD. | Yan, X., et al. 2007. Protein Sci. 16: 2491-501. PMID: 17905826
- Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. | Nahoum, V., et al. 2007. Proc Natl Acad Sci U S A. 104: 17323-8. PMID: 17947383
- Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. | le Maire, A., et al. 2009. EMBO Rep. 10: 367-73. PMID: 19270714
- Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. | Pérez Santín, E., et al. 2009. J Med Chem. 52: 3150-8. PMID: 19408900
- Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos. | Zhu, J., et al. 2014. Environ Toxicol Pharmacol. 38: 153-62. PMID: 24950139
- A representative retinoid X receptor antagonist UVI3003 induced teratogenesis in zebrafish embryos. | Zheng, L., et al. 2015. J Appl Toxicol. 35: 280-6. PMID: 25186191
- β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor. | Sun, J., et al. 2014. J Biol Chem. 289: 33118-24. PMID: 25324544
- Quantitative toxicoproteomic analysis of zebrafish embryos exposed to a retinoid X receptor antagonist UVI3003. | Zheng, L., et al. 2015. J Appl Toxicol. 35: 1049-57. PMID: 25581642
- The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. | Zhu, J., et al. 2017. Toxicol Appl Pharmacol. 314: 91-97. PMID: 27894914
- Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. | Hebert, SL., et al. 2017. Exp Cell Res. 361: 101-111. PMID: 29017757
- RXR Ligands Modulate Thyroid Hormone Signaling Competence in Young Xenopus laevis Tadpoles. | Mengeling, BJ., et al. 2018. Endocrinology. 159: 2576-2595. PMID: 29762675
- Anti-inflammatory effects of minocycline are mediated by retinoid signaling. | Clemens, V., et al. 2018. BMC Neurosci. 19: 58. PMID: 30241502
- The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats. | Murillo-Rodríguez, E., et al. 2020. Psychopharmacology (Berl). 237: 2055-2073. PMID: 32472163
- Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells? | Latta, L., et al. 2021. Biomolecules. 11: PMID: 34827649
- Retinoid-X receptor agonists increase thyroid hormone competence in lower jaw remodeling of pre-metamorphic Xenopus laevis tadpoles. | Mengeling, BJ., et al. 2022. PLoS One. 17: e0266946. PMID: 35417489
Inhibitor of:
RXR, RXRα, RXRβ, ZMYND17, ZNF430, and ZNF764.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UVI 3003, 10 mg | sc-358586 | 10 mg | $168.00 | |||
UVI 3003, 50 mg | sc-358586A | 50 mg | $714.00 |