URB-754 was originally described as a potent and selective inhibitor of MAG lipase which selectively raises levels of 2-arachidonoylglycerol (2AG). Subsequent studies have shown that that URB-754 does not inhibit recombinant MAG Lipase and that the original activity was due to a contaminant, bis(methylthio)mercurane, in another commercial source. URB-754 is an inhibitor of FAAH.
1. Makara, J.K., et al. 2005. Nat. Neurosci. 8: 1139-1141. PMID: 16116451 2. Saario, S.M., et al. 2006. Chem. Biol. 13: 811-814. PMID: 16931330 3. Vandevoorde, S., et al. 2007. Brit. J. Pharmacol. 150: 186-191. PMID: 17143303
Soluble in DMSO (15 mg/mL), and DMF. Insoluble in water.
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