UDP disodium saltA P2Y6 receptor agonist and GPR105 receptor inhibitor

UDP disodium salt (CAS 27821-45-0)

UDP disodium salt | CAS 27821-45-0 is rated 5.0 out of 5 by 1.
  • y_2019, m_12, d_9, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204372, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 119ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: Uridine-5'-diphosphate disodium salt
Application: A P2Y6 receptor agonist and GPR105 receptor inhibitor
CAS Number: 27821-45-0
Purity: ≥97%
Molecular Weight: 448.12
Molecular Formula: C9H12N2O12P22Na
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

UDP disodium salt is an endogenous P2Y receptor agonist, which specifically activates P2Y6 receptors. It is known that UDP disodium salt can also function as a competitive antagonist at GPR105 (P2Y14) receptors. UDP disodium salt is composed of a pyrophosphate, ribose, and a uracil group, with the pyrophosphate esterified to the C5 of the sugar moiety. P2Y receptors are G-protein coupled receptors which are activated by nucleotides, with P2Y6 known to interact specifically with UDP, ADP, and UTP. Studies suggest that P2Y6 is an important component in activating p38 MAPK-mediated COX-2 expression.


References

1. Ralevic, V. and Burnstock, G. 1998. Pharmacol. Rev. 50: 413-492. PMID: 9755289
2. Fricks, I.P., et al. 2008. J. Pharmacol. Exp. Ther. 325: 588-594. PMID: 18252808

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at -20° C
Melting Point :
195° C (dec.)
Refractive Index :
n20D ~1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11957711
MDL Number :
MFCD00149253
EC Number :
248-678-9
Beilstein Registry :
8817400
SMILES :
C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)[O-])O)O.[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 68ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Fricks Fricks, IP. et al. (PubMed 18252808) reported that UDP is a competitive antagonist at the human P2Y14 receptor. -SCBT Publication Review
Date published: 2015-06-17
  • y_2019, m_12, d_9, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204372, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 32ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.