UBP 282A receptor antagonist that distinguishes between motoneuron and dorsal root kainate receptors

UBP 282 (CAS 544697-47-4)

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Synonym: 3-CBW; (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
Application: A receptor antagonist that distinguishes between motoneuron and dorsal root kainate receptors
CAS Number: 544697-47-4
Purity: >98%
Molecular Weight: 333.3
Molecular Formula: C15H15N3O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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UBP 282 is an GluR (AMPA and kainate receptor) antagonist that distinguishes between motoneuron and dorsal root kainate receptors. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.


References

1. More, J.C., et al. 2002. Br. J. Pharmacol. 137: 1125-1133.
2. More, J.C., et al. 2003. Br. J. Pharmacol. 138: 1093-1100.

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (100 mM), and 1eq. HCl (25 mM).
Storage :
Store at room temperature
Melting Point :
327.83° C (Predicted)
Boiling Point :
~612.6° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Glutamate receptor ionotropic, AMPA: IC50 = 10.3 µM (rat)
Ki Data :
Glutamate receptor ionotropic, AMPA: Ki= 13.4 µM (rat); Glutamate receptor ionotropic kainate 2: Ki>100 µM (rat)
pK Values :
pKa: 2.12 (Predicted), pKb: 9.03 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6604912
MDL Number :
MFCD06411590
SMILES :
C1=CC(=CC=C1CN2C(=O)C=CN(C2=O)C[C@@H](C(=O)O)N)C(=O)O

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Certificate of Analysis

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