UBP 282 is an GluR (AMPA and kainate receptor) antagonist that distinguishes between motoneuron and dorsal root kainate receptors. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
1. More, J.C., et al. 2002. Br. J. Pharmacol. 137: 1125-1133. 2. More, J.C., et al. 2003. Br. J. Pharmacol. 138: 1093-1100.
Soluble in 1eq. NaOH (100 mM), and 1eq. HCl (25 mM).
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