Ubiquitin Isopeptidase Inhibitor II, F6CAS: 157654-67-6 (HCl salt)
MF: C21H21NO
MW: 303.4
A cell-permeable caspase activation and apoptosis inducer.

Ubiquitin Isopeptidase Inhibitor II, F6 (CAS 157654-67-6 (HCl salt))

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Application: A cell-permeable caspase activation and apoptosis inducer
CAS Number: 157654-67-6 (HCl salt)
Molecular Weight: 303.4
Molecular Formula: C21H21NO
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ubiquitin Isopeptidase Inhibitor II, F6 is a cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 15.65 and 16.23 μM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway, selectively inhibiting USP (ubiquitin isopeptidase) activity. The cellular expression of Bax and Bak is essential for F6-activated apoptosis, while Bcl-2 appears to protect cells against the effect of F6.


Aleo, E., et al. 2006. Cancer Res. 66, 9235.

Usage :
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Physical State :
Solubility :
Soluble in DMSO (5 mg/ml), and methanol (1 mg/ml).
Storage :
Store at 4° C
Melting Point :
186.51° C (Predicted)
Boiling Point :
522.72° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
CEM: IC50 = 1.69 µM (human); ADMET: IC50 = 1.69 µM (human); apoptosis: IC50 = 15.65 µM (E1A cell); apoptosis: IC50 = 16.23 µM (E1A/C9DN cells); L1210: IC50 = 8.47 µM (mouse)
pK Values :
pKb: 5.92
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

Download SDS (MSDS)

Certificate of Analysis

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