Ubiquitin Isopeptidase Inhibitor I, G5A cell-permeable cross-conjugated unsaturated dienone compound

Ubiquitin Isopeptidase Inhibitor I, G5 (CAS 108477-18-5)

Ubiquitin Isopeptidase Inhibitor I, G5 | CAS 108477-18-5 is rated 5.0 out of 5 by 1.
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Synonym: 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one
Application: A cell-permeable cross-conjugated unsaturated dienone compound
CAS Number: 108477-18-5
Purity: ≥97%
Molecular Weight: 414.4
Molecular Formula: C19H14N2O7S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated α,β-unsaturated dienone compound reported to induce caspase activation and apoptosis via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is reported to exhibit similar pharmacological effects as Ubiquitin Isopeptidase Inhibitor II, F6 but is reported to be more potent (sc-296678). Additionally, at higher concentrations, it has been shown to induce necrosis in apoptosis-resistant MEFs-DKO.


References

1. Aleo, E., et al. 2006. Cancer Res. 66: 9235-9244. PMID: 16982768
2. Fontanini, A., et al. 2009. J. Biol. Chem. 284: 8369-8381. PMID: 19139105

Physical State :
Solid
Solubility :
Solubility: DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5918438
SMILES :
O=C1/C(=C/c2ccc(cc2)[N+](=O)[O-])/CS(=O)(=O)C/C/1=Cc1ccc(cc1)[N+](=O)[O-]

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Ubiquitin Isopeptidase Inhibitor I, G5  Product Citations

See how others have used Ubiquitin Isopeptidase Inhibitor I, G5. Click on the entry to view the PubMed entry .

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PMID: # 25959059  Koumbadinga, GA. et al. 2015. Biochimica et biophysica acta. 1849: 1095-103.

PMID: # 24985478  Rush, J.S. et al. 2014. Investigative ophthalmology & visual science. 55: 4691-9.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Fontanini et al Fontanini et al. (PubMed ID 19139105) used Ubiquitin Isopeptidase Inhibitor I, G5 to kill apoptosis- resistant mouse embryo DKO cells by reorganizing the cytoskeleton and promoting necrosis. -SCBT Publication Review
Date published: 2015-03-03
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