Ubiquinone-10An inhibitor of the mitochondrial permeability transition pore

Ubiquinone-10 (CAS 606-06-4)

Ubiquinone-10 | CAS 606-06-4 is rated 5.0 out of 5 by 1.
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Synonym: Coenzyme Q2; 2,3-Dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone
Application: An inhibitor of the mitochondrial permeability transition pore
CAS Number: 606-06-4
Purity: ≥90%
Molecular Weight: 318.4
Molecular Formula: C19H26O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ubiquinone-10 acts as an inhibitor of the mitochondrial permeability transition pore (MPTP). This inhibitory effect can be counteracted by ubiquinone-5.


References

1. Wilkerson, M.K. et al. 2006. Am. J. Physiol. Heart Circ. Physiol. 290(1): H240-H247. PMID: 16113072

Physical State :
Liquid
Solubility :
Soluble in acetone (50 mg/ml), and water (Partly miscible).
Storage :
Store at -20° C
Melting Point :
158.22° C (Predicted)
Boiling Point :
465.78° C at 760 mmHg (Predicted)
Density :
~1.1 g/mL (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5280346
MDL Number :
MFCD00871693
Beilstein Registry :
2059805
SMILES :
CC1=C(C(=O)C(=C(C1=O)OC)OC)CC=C(C)CCC=C(C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wilkerson et al Wilkerson et al. (PubMed ID 16113072) used xestospongin C to inhibit IP3R opening in order to prevent FBS-induced calcium waves in the arterial monocytes of mice brains. -SCBT Publication Review
Date published: 2015-02-01
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