UA62784A centromere protein E (CENP-E) inhibitor

UA62784 (CAS 313367-92-9)

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Synonym: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
Application: A centromere protein E (CENP-E) inhibitor
CAS Number: 313367-92-9
Purity: ≥98%
Molecular Weight: 353.37
Molecular Formula: C23H15NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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UA62784 is a fluorenone specific inhibitor of CENP-E(centromere protein E), which is a kinesin-like motor protein. It is known that CENP-E migrates towards the kinetochore during mitosis and is essential in spindle formation. UA62784 acts as a specific inhibitor of CENP-E via binding to the motor domain of the protein. As a result of this inhibition cell cycle arrest occurs during metaphase via inhibiting chromosome congregation at the metaphase plate. It is believed that this is a result of UA62784's ability to inhibit CENP-E microtubule associated ATPase activity. Furthermore, UA62784 can selectively destroy pancreatic cancer locus 4-deficient cancer cells.


References

1. Henderson, M.C., et al. 2009. Mol. Cancer Ther. 8: 36-44. PMID: 19139111
2. Wang, H., et al. 2009. Pancreas. 38: 551-557. PMID: 19276868

Appearance :
Powder
Physical State :
Solid
Solubility :
Solubility: Soluble in DMSO and Water
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3383533
MDL Number :
MFCD00489199
SMILES :
COC1=CC=C(C=C1)C2=CN=C(O2)C3=C4C5=CC=CC=C5C(=O)C4=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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