U 92016A CAS: 149654-41-1
MF: C19H25N3 HCl
MW: 331.88
A selective SR-1A agonist.

U 92016A (CAS 149654-41-1)

U 92016A | CAS 149654-41-1 is rated 5.0 out of 5 by 1.
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Alternate Names: (8R)-8-(Dipropylamino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-2-carbonitrile hydrochloride (1:1)
Application: U 92016A is a selective SR-1A agonist
CAS Number: 149654-41-1
Purity: ≥99%
Molecular Weight: 331.88
Molecular Formula: C19H25N3 HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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U 92016A is a selective SR-1A (5-HT1A receptor) agonist that displays high intrinsic activity (Ki values are 0.4, 7.7 and 36 nM for 5-HT1A, SR-1D (5-HT1D) and D2 receptors respectively and > 1000 nM for 5-HT2, D1, α1 and α2 receptors). Produces hypotension, hypothermia and 5-HT behavioral syndrome following p.o. administration.


References

Romero et al (1993) Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J.Med.Chem. 36 2066. McCall et al (1994) Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J.Pharmacol.Exp.Ther. 271 875.

Physical State :
Solid
Solubility :
Soluble in water (10 mM), and DMSO (100 mM).
Storage :
Store at 4° C
Refractive Index :
n20D 1.60 (Predicted)
Ki Data :
SR-1A: Ki= 0.1 nM (human); Serotonin 1a (5-HT1a) receptor: Ki= 1.7 nM (rat); D2DR: Ki= 35 nM (human); Dopamine D2 receptor: Ki= 538 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD00920890
SMILES :
CCCN(CCC)[[email protected]@H]1CCc2ccc3c(c2C1)cc([nH]3)C#N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from McCall et al McCall et al. (PubMed ID 7965808) found that U-92016A decreased the forskolin-induced increase in cyclic AMP synthesis via 5HT1A receptor activation in chinese hamster ovary cells. -SCBT Publication Review
Date published: 2015-01-05
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