U 18666AA cell-permeable amphiphilic amino-steroid

U 18666A (CAS 3039-71-2)

U 18666A | CAS 3039-71-2 is rated 5.0 out of 5 by 1.
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Synonym: (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
Application: A cell-permeable amphiphilic amino-steroid
CAS Number: 3039-71-2
Purity: >95%
Molecular Weight: 424.06
Molecular Formula: C25H41NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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U 18666A is a cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol, presumably via its inhibitory effect on 2,3-oxidosqualene-lanosterol cyclase activity. It is also a weak inhibitor of hedgehog (Hh) signaling.


References

Hall, A.M., et al. 2003. Pigment Cell Res. 16, 149. Kobayashi, T., et al. 1998. Nature 392, 193. Liscum, L. and Faust, J.R., 1989. J. Biol. Chem. 264, 11796. Sexton, R.C., et al. 1983. Biochemistry 22, 5687. Bierkamper, G.G. and Cenedella, R.J., 1978. Brain Res. 150, 343

Physical State :
Solid
Solubility :
Soluble in water (10 mg/mL), ethanol (~20 mg/mL), DMF (~10 mg/mL), PBS pH 7.2 (~0.5 mg/mL), and DMSO (~10 mg/mL).
Storage :
Store at 4° C
Melting Point :
195-196.5° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
18224
MDL Number :
MFCD00210908
SMILES :
CCN(CC)CCOC1CCC2=CCC3C4CCC(=O)C4(CCC3C2(C1)C)C.Cl

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Certificate of Analysis

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U 18666A  Product Citations

See how others have used U 18666A. Click on the entry to view the PubMed entry .

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PMID: # 23774297  2013. Biochimie. 95: 1677-88.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yamasaki et al Yamasaki et al. (PubMed ID 25181483) found that U 18666A partly antagonized PrP(Sc) prion protein degradation. -SCBT Publication Review
Date published: 2015-05-07
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