U 18666A is a cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol, presumably via its inhibitory effect on 2,3-oxidosqualene-lanosterol cyclase activity. It is also a weak inhibitor of hedgehog (Hh) signaling.
Hall, A.M., et al. 2003. Pigment Cell Res. 16, 149. Kobayashi, T., et al. 1998. Nature 392, 193. Liscum, L. and Faust, J.R., 1989. J. Biol. Chem. 264, 11796. Sexton, R.C., et al. 1983. Biochemistry 22, 5687. Bierkamper, G.G. and Cenedella, R.J., 1978. Brain Res. 150, 343
Soluble in water (10 mg/mL), ethanol (~20 mg/mL), DMF (~10 mg/mL), PBS pH 7.2 (~0.5 mg/mL), and DMSO (~10 mg/mL).
Store at 4° C
195-196.5° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
U 18666A Product Citations
See how others have used U 18666A. Click on the entry to view the PubMed entry
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.