Tyrphostin B44, (+) enantiomerAn EGFR kinase inhibitor

Tyrphostin B44, (+) enantiomer (CAS 133550-37-5)

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Synonym: Tyrphostin B50; (+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
Application: An EGFR kinase inhibitor
CAS Number: 133550-37-5
Molecular Weight: 308.34
Molecular Formula: C18H16N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tyrphostin B44, (+) enantiomer is the EGFR (epidermal growth factor receptor) kinase inhibitor (IC50 = 0.86 µM). Slightly less active than the (-) enantiomer


References

1. Gazit, A., et al. 1991. J. Med. Chem. 34: 1896-1907. PMID: 1676428

Physical State :
Solid
Solubility :
Soluble in DMSO (30 mM), and ethanol (100%). Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
603.01° C at 760 mmHg (Predicted)
Density :
1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
The inhibition of EGFR-kinase activity: IC50 = 860 nM
pK Values :
pKa: 8.81 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5328769
MDL Number :
MFCD00209855
SMILES :
N#CC(=CC1=CC(=C(C=C1)O)O)C(=O)N[C@H](C)C2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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