Tyrphostin 47 is a protein tyrosine kinase inhibitor particularly potent against epidermal growth factor receptor (EGFR) kinase activity. Tyrphostin 47 has been observed to inhibit GTPase activity of transducin and the homologous insulin receptor kinase. It has also been found to also inhibit hyperactive motility of hamster spermatozoa. Tyrphostin 47 interferes with the proximal EGFR signaling pathway, causes G1-S transition arrest, and induces apoptosis in the human MCF-7 breast cancer cell line. In vero cell cultures, this product induced cell death and p38 MAPK phosphorylation.
1. Gazit, A., et al. 1989. J. Med. Chem. 32: 2344-2352. PMID: 2552117
2. Turbov, J.M., et al. 2002. J Surg Oncol. 79: 17-29. PMID: 11754373
3. Ikeda, M., et al. 2006. Eur. J. Pharmacol. 546: 36-39. PMID: 16919262
4. Mariappa, D., et al. 2006. Mol. Reprod. Dev. 73: 215-225. PMID: 16220544
See how others have used Tyrphostin 47. Click on the entry to view the PubMed entry .
PMID: # 27872081 Guyett, PJ. et al. 2017. Antimicrob. Agents Chemother. 61:
PMID: # 12117110 Lorenzo, PL. et al. 2002. Equine Vet. J. 34: 378-382.
PMID: # 2788167 Lyall, RM. et al. 1989. J. Biol. Chem. 264: 14503-14509.
PMID: # 25715600 Ermakov, AM. et al. Biofizika. 59: 552-7.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.
Email address is required. Please provide a valid email address.
{* #socialRegistrationForm *} {* emailAddress *} {* firstName *} {* lastName *}