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Tylosin 3-Acetate (CAS 63409-10-9)

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Alternate Names:
3-O-Acetyltylosin
CAS Number:
63409-10-9
Molecular Weight:
958.14
Molecular Formula:
C48H79NO18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tylosin 3-Acetate is a macrolide antibiotic that belongs to the polyketide family and is derived from tylosin, an antibiotic produced by Streptomyces fradiae. Tylosin 3-Acetate works by inhibiting the production of protein in bacteria, which prevents the bacteria from replicating and causing infection. It has been used in a variety of scientific research applications, including the study of bacterial resistance to antibiotics, the development of new antibiotics, and the study of the effects of antibiotics.


Tylosin 3-Acetate (CAS 63409-10-9) References

  1. Rapid multi-residue screening of antibiotics in muscle and kidney by liquid chromatography-electrospray ionization-tandem mass spectrometry.  |  Granelli, K. and Branzell, C. 2007. Anal Chim Acta. 586: 289-95. PMID: 17386726
  2. Multi-method for the determination of antibiotics of different substance groups in milk and validation in accordance with Commission Decision 2002/657/EC.  |  Bohm, DA., et al. 2009. J Chromatogr A. 1216: 8217-23. PMID: 19615688
  3. Stability study for 53 antibiotics in solution and in fortified biological matrixes by LC/MS/MS.  |  Gaugain, M., et al. 2013. J AOAC Int. 96: 471-80. PMID: 23767376
  4. Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation.  |  Zhao, Z., et al. 2014. Biochem Pharmacol. 90: 73-87. PMID: 24792436
  5. Immobilization of Streptomyces thermotolerans 11432 on polyurethane foam to improve production of acetylisovaleryltylosin.  |  Zhu, H., et al. 2015. J Ind Microbiol Biotechnol. 42: 105-11. PMID: 25413211
  6. Screening and confirmatory method for multiclass determination of 62 antibiotics in meat.  |  Moretti, S., et al. 2016. J Chromatogr A. 1429: 175-88. PMID: 26726937
  7. Concentrations of tylvalosin and 3-O-acetyltylosin attained in the synovial fluid of swine after administration by oral gavage at 50 and 5 mg/kg.  |  Canning, P., et al. 2016. J Vet Pharmacol Ther. 39: 621-624. PMID: 27086612
  8. Multiclass method for the determination of 62 antibiotics in milk.  |  Moretti, S., et al. 2016. J Mass Spectrom. 51: 792-804. PMID: 27490945
  9. Variation in water disappearance, daily dose, and synovial fluid concentrations of tylvalosin and 3-O-acetyltylosin in commerical pigs during five day water medication with tylvalosin under field conditions.  |  Canning, P., et al. 2018. J Vet Pharmacol Ther. 41: 632-636. PMID: 29572923
  10. Transfer of a Multiclass Method for over 60 Antibiotics in Food from High Resolution to Low Resolution Mass Spectrometry.  |  Giusepponi, D., et al. 2019. Molecules. 24: PMID: 31412663
  11. Targeted and non-targeted unexpected food contaminants analysis by LC/HRMS: Feasibility study on rice.  |  Wang, T., et al. 2021. Food Chem. 338: 127957. PMID: 32919373
  12. Determination of macrolides in animal tissues and egg by multi-walled carbon nanotube-based dispersive solid-phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry.  |  Du, J., et al. 2021. Food Chem. 365: 130502. PMID: 34252621
  13. Validated Screening Method for 81 Multiclass Veterinary Drug Residues in Food via Online-Coupling High-Throughput Planar Solid-Phase Extraction to High-Performance Liquid Chromatography-Orbitrap Tandem Mass Spectrometry.  |  Mehl, A., et al. 2022. J Agric Food Chem. 70: 10886-10898. PMID: 36018326
  14. Binding of 3-O-acetyl-4'-O-isovaleryltylosin to ribosomes from a macrolide-resistant strain of Staphylococcus aureus.  |  Tsuchiya, M., et al. 1982. J Antibiot (Tokyo). 35: 673-9. PMID: 7118723
  15. Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae.  |  Arisawa, A., et al. 1996. J Antibiot (Tokyo). 49: 349-54. PMID: 8641997

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tylosin 3-Acetate, 0.5 mg

sc-474025
0.5 mg
$549.00