TX-1918 CAS: 503473-32-3
MF: C14H12O3
MW: 228.25
A potent inhibitor for eEF2K.

TX-1918 (CAS 503473-32-3)

TX-1918 | CAS 503473-32-3 is rated 5.0 out of 5 by 1.
  • y_2022, m_5, d_28, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.27
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_296676, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 113ms
  • REVIEWS, PRODUCT
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: 2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
Application: TX-1918 is a potent inhibitor for eEF2K
CAS Number: 503473-32-3
Molecular Weight: 228.25
Molecular Formula: C14H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

TX-1918 may be useful as a therapeutic agent for cancer treatment in animal models. A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eukaryotic elongation factor-2 kinase (eEF2K, IC50 = 440 nM). At higher concentrations, TX-1918 has been shown to inhibit other kinases, including proto-oncogene tyrosine-protein kinase Src (c-SRC, IC50 = 4.4 μM), protein kinase A and C (PKA and PKC, IC50 = 44 μM for each), and epidermal growth factor receptor kinase (EGFR-K, IC50 = 440 μM).

Additionally, TX-1918 has been reported to exhibit potent anti-tumor activity in HepG2 (EC50 = 2.07) and HCT116 (EC50 = 230 μM) tumor cells, with greatly reduced mitochondrial- (≥5000-fold) and hepato-toxicity (≥90-fold) when compared with another tyrphostin, AG 17 (sc-200568).


References

1. Hori, Hitoshi., et al., 2002. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorganic & medicinal chemistry. 10(10): 3257-65. PMID: 12150871

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
151.37° C (Predicted)
Boiling Point :
~436.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
eEF2K: IC50 = 0.44 µM (human); c-Src: IC50 = 4.4 µM; PKA: IC50 = 44 µM; PKC: IC50 = 44 µM; EGFR-K: IC50 = 440 µM
pK Values :
pKa: 9.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC1=CC(=CC(=C1O)C)C=C2C(=O)C=CC2=O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

TX-1918 (CAS 503473-32-3)  Product Citations

See how others have used TX-1918 (CAS 503473-32-3). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 33662272  Shen, Y.|Zhang, ZC.|Cheng, S.|Liu, A.|Zuo, J.|Xia, S.|Liu, X.|Liu, W.|Jia, Z.|Xie, W.|Han, J.| et al. 2021. Mol Cell. 81: 1425-1438.e10.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 107ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Various publications cite the use of the Various publications cite the use of the eEF2K inhibitor, TX-1918, as an antitumor agent. -SCBT Publication Review
Date published: 2015-02-09
  • y_2022, m_5, d_28, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.27
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_296676, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT