Tubulozole CAS: 84697-22-3
MF: C23H23Cl2N3O4S•HCl
MW: 544.9
A stereospecific microtubule inhibitor.

Tubulozole (CAS 84697-22-3)

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Synonym: Tubulozole hydrochloride
Application: A stereospecific microtubule inhibitor
CAS Number: 84697-22-3
Molecular Weight: 544.9
Molecular Formula: C23H23Cl2N3O4S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tubulozole is a stereospecific microtubule inhibitor. Tests show the compound to have distinct antineoplastic properties in vivo by prolonging the median survival time of neoplasms: MO4 sarcoma, L1210 leukemia and TA3 carcinoma. Activity of tubulazole resides in the cis isomer, while the trans isomer has no effect at all.


References

The effects of tubulazole, a new synthetic microtubule inhibitor on experimental neoplasms: R. Van Ginckel, et al.; Eur. J. Canc. Clin. Oncol. 20, 99 (1984) Effects of tubulozole on the microtubule system of cells in culture and in vivo: G.M.A. Geuens, et al.; Cancer Res. 45, 733 (1985)

Physical State :
Solid
Solubility :
Soluble in methanol, 100% ethanol, dimethylformamide or DMSO; almost insoluble in water.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44134980
SMILES :
CCOC(=O)NC1=CC=C(C=C1)SCC2COC(O2)(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl.Cl

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Certificate of Analysis

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