Tubulin Polymerization InhibitorAn antimicrotubule agent

Tubulin Polymerization Inhibitor (CAS 564468-51-5)

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Application: An antimicrotubule agent
CAS Number: 564468-51-5
Molecular Weight: 328.37
Molecular Formula: C22H16O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tubulin Polymerization Inhibitor is a low molecular weight, cell-permeable, benzylidene-anthracenone antimicrotubule agent that exhibits potent antitumor activity (IC50 = 20 and 50 nM in inhibiting Tumor cell growth in K562 and SKOV3 cells, respectively) comparable to other commonly used antitumor agents. Unlike Paclitaxel , Vinblastine , or Vincristine , it does not function as a substrate for Pgp-170 and exhibits cytotoxic effects towards tumor cell lines with various MDR resistance phenotypes. It is shown to interact with Tubulin at the Colchicine, but not the Vinblastine, binding site.


References

1. Prinz, H., et al. 2003. J. Med. Chem. 46: 3382-3394. PMID: 19220018

Physical State :
Solid
Solubility :
Soluble in DMSO (1 mg/ml).
Storage :
Store at 4° C
Density :
~1.30 g/cm3 (Predicted)
Refractive Index :
n20D ~1.70 (Predicted)
IC50 :
RXF 944: IC50 = 10 nM (human); MCF7: IC50 = 10 nM (human); Human breast 401NL tumor cell line: IC50 = 10 nM (human); NCI-H460: IC50 = 10 nM (human)
pK Values :
pKa: 9.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10125800
MDL Number :
MFCD06411568
SMILES :
COC1=C(C=C(C=C1)C=C2C3=CC=CC=C3C(=O)C4=CC=CC=C42)O

Download SDS (MSDS)

Certificate of Analysis

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