Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2). Tubacin does not inhibit HDAC6 histone deacetylase activity. Instead, it reversibly inhibits α-tubulin deacetylation. Tubacin increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.
Rated 5 out of
YuanYuan, L. et al. (PubMed 25976407) observed that inhibiting the activity of HDAC6 with Tubacin, a specific HDAC6 inhibitor, reduced the oxygen-glucose deprivation (OGD)-induced necroptosis of cultured rat cortical neurons. In addition, inhibiting the activity of HDAC6 reversed the OGD-induced increase of reactive oxygen species (ROS) and the OGD-induced decrease of acetylated tubulin in the cultured rat cortical neurons. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.