TTP 22 CAS: 329907-28-0
MF: C16H14N2O2S2
MW: 330.42
A casein kinase 2 (CK2) inhibitor.

TTP 22 (CAS 329907-28-0)

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Alternate Names: 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid
Application: TTP 22 is a casein kinase 2 (CK2) inhibitor
CAS Number: 329907-28-0
Purity: 99%
Molecular Weight: 330.42
Molecular Formula: C16H14N2O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1μM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 μM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (20 mM).
Storage :
Store at 4° C
Melting Point :
188-190° C
Boiling Point :
~575.0° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
CK2: IC50 = 0.1 µM
Ki Data :
CK2: Ki= 40 nM
pK Values :
pKa: 4.03 (Predicted), pKb: 0.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD02654497
SMILES :
CC1=CC=C(C=C1)C2=CSC3=C2C(=NC=N3)SCCC(=O)O

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Certificate of Analysis

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TTP 22 (CAS 329907-28-0)  Product Citations

See how others have used TTP 22 (CAS 329907-28-0). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30249660  Proc. Natl. Acad. Sci. U.S.A. 115: E9570-E9579.

Citations 1 to 1 of 1 total
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