TSSK 1B Antibody (NQ-A36): sc-135590

TSSK 1B Antibody (NQ-A36) is a mouse monoclonal IgG1 kappa light chain antibody that detects the TSSK 1B protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TSSK 1B antibody (NQ-A36) is available as the non-conjugated format. TSSK 1B, or Testis-specific serine/threonine-protein kinase 1B, is a crucial protein involved in the regulation of spermatogenesis, specifically during the late stages of cytodifferentiation in spermatids within the seminiferous tubules. This 367 amino acid protein, which belongs to the serine/threonine protein kinase family, contains a single protein kinase domain and utilizes magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins. Phosphorylation of TSSK 1B at Thr 174, likely through autophosphorylation, is essential for activation and function. TSSK 1B interacts with TSSK 2, highlighting a role in a network of proteins that regulate spermatogenesis. Precise localization of TSSK 1B in the cytoplasm of spermatids underscores importance in the final stages of sperm cell development, making TSSK 1B a significant marker for studies related to male fertility and reproductive health.

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TSSK 1B Antibody (NQ-A36) References:

1. A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice.  |  Zuercher, G., et al. 2000. Mech Dev. 93: 175-7. PMID: 10781952
2. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.  |  Hao, Z., et al. 2004. Mol Hum Reprod. 10: 433-44. PMID: 15044604
3. TSKS concentrates in spermatid centrioles during flagellogenesis.  |  Xu, B., et al. 2008. Dev Biol. 319: 201-10. PMID: 18495105
4. Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.  |  Xu, B., et al. 2008. Dev Biol. 319: 211-22. PMID: 18533145
5. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.  |  Hanks, SK., et al. 1988. Science. 241: 42-52. PMID: 3291115
6. A novel family of serine/threonine kinases participating in spermiogenesis.  |  Kueng, P., et al. 1997. J Cell Biol. 139: 1851-9. PMID: 9412477
7. ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene.  |  Lindsay, EA., et al. 1998. Hum Mol Genet. 7: 629-35. PMID: 9499415
8. Immunohistochemical analysis of the expression of two serine-threonine kinases in the maturing mouse testis.  |  Nayak, S., et al. 1998. Mech Dev. 74: 171-4. PMID: 9651519
9. Cloning and comparative mapping of the DiGeorge syndrome critical region in the mouse.  |  Sutherland, HF., et al. 1998. Genomics. 52: 37-43. PMID: 9740669

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TSSK 1B Antibody (NQ-A36) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TSSK 1B Antibody (NQ-A36) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TSSK 1B Antibody (NQ-A36) Specifications

Alternate Product Name: TSSK 1B

Product Clone Name: NQ-A36

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 267-367

Epitope Target: TSSK 1B

Epitope Species: human

Product Reactivity/Detection: TSSK 1B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TSSK 1B Antibody (NQ-A36): N/A