TryptanthrinA potent inhibitor of Cox-2 and NOS II

Tryptanthrin (CAS 13220-57-0)

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Synonym: Indolo(2,1-b)quinazoline-6,12-dione
Application: A potent inhibitor of Cox-2 and NOS II
CAS Number: 13220-57-0
Purity: ≥98%
Molecular Weight: 248.24
Molecular Formula: C15H8N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tryptanthrin is a potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Tryptanthrin is a selective inhibitor of cyclooxygenase-2 (Cox-2). Tryptanthrin is an inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Tryptanthrin inhibits the production of IFN-γ and IL-2 after stimulation of Peyer patch lymphocytes with staphylococcal enterotoxin B (SEB). Tryptanthrin inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin resistance on breast cancer cells.


References

1. H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000). 2. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001). 3. Inhibitory activity of tryptanthrin on prostaglandi

Appearance :
Needles
Physical State :
Solid
Solubility :
Soluble in DMSO (8 mg/ml), methanol (0.3 mg/ml), and water (sparingly, 2.5 µg/ml).
Storage :
Store at 4° C
Melting Point :
184.06° C (Predicted)
Boiling Point :
469.35° C at 760 mmHg (Predicted)
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
Cox-2: IC50 = 64 nM (human); 5-LO: IC50 = 150 nM (human); Plasmodium yoelii: IC50 = 225.1 nM; HEK293: IC50 = 4.11 µM (human); DU-145: IC50 = 6.22 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
73549
MDL Number :
MFCD00012073
SMILES :
C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2

Download SDS (MSDS)

Certificate of Analysis

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