TryptanthrinA potent inhibitor of Cox-2 and NOS II

Tryptanthrin (CAS 13220-57-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 56ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Indolo(2,1-b)quinazoline-6,12-dione
Application: A potent inhibitor of Cox-2 and NOS II
CAS Number: 13220-57-0
Purity: ≥98%
Molecular Weight: 248.24
Molecular Formula: C15H8N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Tryptanthrin is a potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Tryptanthrin is a selective inhibitor of cyclooxygenase-2 (Cox-2). Tryptanthrin is an inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Tryptanthrin inhibits the production of IFN-γ and IL-2 after stimulation of Peyer patch lymphocytes with staphylococcal enterotoxin B (SEB). Tryptanthrin inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin resistance on breast cancer cells.


1. H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000). 2. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001). 3. Inhibitory activity of tryptanthrin on prostaglandi

Appearance :
Physical State :
Solubility :
Soluble in DMSO (8 mg/ml), methanol (0.3 mg/ml), and water (sparingly, 2.5 µg/ml).
Storage :
Store at 4° C
Melting Point :
184.06° C (Predicted)
Boiling Point :
469.35° C at 760 mmHg (Predicted)
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
Cox-2: IC50 = 64 nM (human); 5-LO: IC50 = 150 nM (human); Plasmodium yoelii: IC50 = 225.1 nM; HEK293: IC50 = 4.11 µM (human); DU-145: IC50 = 6.22 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 73ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 64ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.