Tryptanthrin is a potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Tryptanthrin is a selective inhibitor of cyclooxygenase-2 (Cox-2). Tryptanthrin is an inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Tryptanthrin inhibits the production of IFN-γ and IL-2 after stimulation of Peyer patch lymphocytes with staphylococcal enterotoxin B (SEB). Tryptanthrin inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin resistance on breast cancer cells.
1. H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000). 2. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001). 3. Inhibitory activity of tryptanthrin on prostaglandi
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