Trypsin Inhibitor, soybean (CAS 9035-81-8)

5.0(1)

Alternate Names: Trypsin Inhibitor, soybean is also known as SBTI.

Application: Trypsin Inhibitor, soybean is a protein and inhibitor of trypsin factor Xa, plasmin and neutrophil elastase.

CAS Number: 9035-81-8

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Trypsin Inhibitor, soybean (STI) is a protein which reduces trypsin (a proteolytic enzyme) as well as plasma kallikrein and plasmin. activity. Trypsin Inhibitor, soybean has demonstrated inhibition of human neutrophil elastase at an IC₅₀=0.3nM. At this concentration Trypsin Inhibitor, soybean showed neither cytotoxic nor haemolytic effects on populations of human blood cells. In fibrin matrix, and without toxic effects, Trypsin Inhibitor, soybean had strong inhibitory effect on human umbilical vein endothelial cells migration and tubulogenesis. It has been observed that repeated administration of Trypsin Inhibitor, soybean to rats, especially suckling and young rats, causes the pancreas to enlarge. Trypsin Inhibitor, soybean is also known as SBTI, STI, and Trypsin inhibitor from Glycine max.

References

1. Wilson, P.A., et al. 1978. Gut. 19: 260-266. PMID: 348580

2. Shakiba, Y., et al. 2007. Fitoterapia. 78: 587-589. PMID: 17590534

3. Ribeiro, J.K., et al. 2010. Eur J Pharmacol. PMID: 20624384

Appearance :

Powder

Physical State :

Solid

Derived From :

Soy Bean

Solubility :

Soluble in water (10 mg/ml), phosphate buffers (10 mg/ml), and balanced salt solutions (1 mg/ml).

Storage :

Store at 4° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

MDL Number :

MFCD00082103

EC Number :

232-906-9

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Certificate of Analysis

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Trypsin Inhibitor, soybean (CAS 9035-81-8) Product Citations

See how others have used Trypsin Inhibitor, soybean (CAS 9035-81-8). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 34948204 Prüschenk, S.|Majer, M.|Schreiber, R.|Schlossmann, J.| et al. 2021. Int J Mol Sci. 22:

PMID: # 18466892 Psenicka, M. et al. 2008. Cryobiology. 56: 251-253.

PMID: # 17640870 Conners, R. et al. 2007. J. Biol. Chem. 282: 27760-27768.

PMID: # 17171473 Oshima, K. et al. 2007. J. Assoc. Res. Otolaryngol. 8: 18-31.

PMID: # 16319066 Harikumar, KG. et al. 2006. J. Biol. Chem. 281: 2543-2550.

PMID: # 16982799 Csordás, G. et al. 2006. J. Cell Biol. 174: 915-921.

PMID: # 15644453 Taylor, EB. et al. 2005. Am. J. Physiol. Endocrinol. Metab. 288: E1055-E1061.

PMID: # 16228192 Wang, KJ. et al. 2005. Theor. Appl. Genet. 112: 66-71.

PMID: # 15382080 Kobayashi, H. et al. 2004. Int. J. Cancer. 112: 519-524.

Citations 1 to 10 of 14 total

Rated 5 out of 5 by HC from Kobayashi Kobayashi, et. al. (PubMed ID 15168733) used soy bean trypsin inhibitor to study its effect on enzymatic activity of secreted, extracellular uPA. -SCBT Publication Review

Date published: 2015-03-20

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