TrimidoxA specific ribonucleotide reductase inhibitor

Trimidox (CAS 95933-74-7)

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Synonym: N, 3, 4, 5- tetrahydroxy- benzenecarboximidamide; VF 233
Application: A specific ribonucleotide reductase inhibitor
CAS Number: 95933-74-7
Molecular Weight: 184.2
Molecular Formula: C7H8N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-6 cells with an IC50 value of 35 µM.1


1 Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12) 4316-4321 (1994). 2 Kanno, S., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic & Clinical Pharmacology & Toxicology 98 44-50 (2006).

Physical State :
Solubility :
Soluble in DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1:2 solution of DMSO:PBS (pH 7.2) (~0.3 mg/ml).
Storage :
Store at -20° C
Melting Point :
171.09° C (Predicted)
Boiling Point :
~480.7° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Growth of promyelocytic leukemia HL-60 cells: IC50 = 35 µM (human); Plasmodium falciparum: IC50 = 38 µM
pK Values :
pKa: 8.78 (Predicted), pKb: 3.11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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