TriciribineCAS: 35943-35-2
MF: C13H16N6O4
MW: 320.30
A tricyclic nucleoside that induces apoptosis and has antineoplastic and antiviral activity.

Triciribine (CAS 35943-35-2)

Triciribine | CAS 35943-35-2 is rated 5.0 out of 5 by 1.
  • y_2019, m_12, d_10, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200661, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 101ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: API-2; NSC 154020; Tricyclic Nucleoside; Akt/PKB Signaling Inhibitor-2
Application: A tricyclic nucleoside that induces apoptosis and has antineoplastic and antiviral activity
CAS Number: 35943-35-2
Purity: ≥97%
Molecular Weight: 320.30
Molecular Formula: C13H16N6O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Akt kinase inhibition has been shown to induce apoptosis and cell growth in cancer cell research. Triciribine can selectively inhibit Akt1, Akt2, and Akt3 without inhibiting known upstream activators,PDK1 and PI 3-Kinase, of Akt. Studies show that Triciribine in duces apoptosis and inhibits cell growth in cells that express atypical Akt1. Additionally, Triciribine has antineoplastic and antiviral activity at low micromolar and submicromolar concentrations, and has been demonstrated to inhibit incorporation of amino acids into proteins and purine nucleotide synthesis.


References

. Moore, E.C., et al. 1989. Biochem. Pharmacol. 38: 4037-4044. PMID: 2480791
2. Porcari, A.R., et al. 2000. J. Med. Chem. 43: 2438-2448. PMID: 10882371
3. Yang, L., et al. 2004. Cancer Res. 64: 4394-4399. PMID: 15231645

Physical State :
Solid
Solubility :
Soluble in 1eq. HCl (100 mM), and DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
216.02° C (Predicted)
Boiling Point :
~718.5° C at 760 mmHg (Predicted)
Density :
~2.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
RY8455000
PubChem CID :
65399
SMILES :
CN1C2=NC=NC3=C2C(=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)C(=N1)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Triciribine  Product Citations

See how others have used Triciribine. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 31484936  2019. Nat Commun. 10: 3978.

PMID: # 27864646  Yan, X. et al. 2017. Lasers Med Sci. 32: 169-180.

PMID: # 28663750  Busch, C. et al. 2017. Front Immunol. 8: 703.

PMID: # 27563247  Jiang, Z. et al. 2016. Onco Targets Ther. 9: 4859-66.

PMID: # 26948085  Fu, T. et al. 2016. Acta Pharmacol. Sin. 37: 505-18.

PMID: # 26159930  Feng, J. et al. 2015. Int. J. Biochem. Cell Biol. 66: 59-68.

PMID: # 23946409  Meng, C. et al. 2013. J. Neurosci. 33: 13505-17.

PMID: # 23065720  Huang, L. et al. 2013. J. Cell. Physiol. 228: 1045-59.

PMID: # 24023668  Liu, L. et al. 2013. PLoS ONE. 8: e73038.

PMID: # 22326662  Feng, J. et al. 2012. Cell. Signal. 24: 1116-1125.

Citations 1 to 10 of 14 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 71ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Moore et al Moore et al. (PuNMEd 2480791) found that triciribone inhibited purine synthesis in intact human leukemic lymphoblasts. -SCBT Publication Review
Date published: 2015-03-30
  • y_2019, m_12, d_10, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200661, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 59ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.