Trichostatin C is a fungistatic antibiotic originally isolated from Streptomyces sp. culture broth. Trichostatin C is also a glucoside analog of Trichostatin A (sc-3511) and is noted to be a first example of a glucopyranosyl hydroxamate from nature. This compound has been demonstrated to act as an effective inducer of erythroid differentiation in a murine erythroleukemia cell line (Friend cell line), although less potent than Trichostatin A. Additional studies utilizing murine splenocytes and Trichostatin C note an increase in histone H4 acetylation level in vitro.
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PMID: # 10805579 Hayakawa, Y. et al. 2000. J. Antibiot. 53: 179-183.
PMID: # 2439196 Yoshida, M. et al. 1987. Cancer Res. 47: 3688-3691.