Trichostatin C CAS: 68676-88-0
MF: C23H32N2O8
MW: 464.5
An inducer of erythroid differentiation and histone H4 acetylation level.

Trichostatin C (CAS 68676-88-0)

Trichostatin C | CAS 68676-88-0 is rated 5.0 out of 5 by 1.
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Application: Trichostatin C is an inducer of erythroid differentiation and histone H4 acetylation level
CAS Number: 68676-88-0
Purity: >95%
Molecular Weight: 464.5
Molecular Formula: C23H32N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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Trichostatin C is a fungistatic antibiotic originally isolated from Streptomyces sp. culture broth. Trichostatin C is also a glucoside analog of Trichostatin A (sc-3511) and is noted to be a first example of a glucopyranosyl hydroxamate from nature. This compound has been demonstrated to act as an effective inducer of erythroid differentiation in a murine erythroleukemia cell line (Friend cell line), although less potent than Trichostatin A. Additional studies utilizing murine splenocytes and Trichostatin C note an increase in histone H4 acetylation level in vitro.


References

1. Tsuji, N. and Kobayashi, M. 1978. J. Antibiot. 31: 939-944. PMID: 711616
2. Yoshida, M., et al. 1987. Cancer Res. 47: 3688-3691. PMID: 2439196
3. Kohge, T., et al. 1998. Biochem. Pharmacol. 56: 1359-1364. PMID: 9825735
4. Bieliauskas, A.V. and Pflum, M.K. 2008. Chem Soc Rev. 37: 1402-1413. PMID: 18568166
5. Wang, L., et al. 2009. Immunol. Cell Biol. 87: 195-202. PMID: 19172156

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in methanol and DMSO.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC(C=C(C)C=CC(=O)NOC1C(C(C(C(O1)CO)O)O)O)C(=O)C2=CC=C(C=C2)N(C)C

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Trichostatin C (CAS 68676-88-0)  Product Citations

See how others have used Trichostatin C (CAS 68676-88-0). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 10805579  Hayakawa, Y. et al. 2000. J. Antibiot. 53: 179-183.

PMID: # 2439196  Yoshida, M. et al. 1987. Cancer Res. 47: 3688-3691.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Yoshida et al Yoshida et al. (PubMed ID 2439196) showed Trichostatin C was a potent DMSO-type inducer of erythroid differentiation in murine erythroleukemia cells. -SCBT Publication Review
Date published: 2015-01-08
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