Trehalose dihydrate, cell cultureAn osmolyte, chemical chaperone, and inducer of autophagy

Trehalose dihydrate, cell culture (CAS 6138-23-4)

Trehalose dihydrate, cell culture | CAS 6138-23-4 is rated 5.0 out of 5 by 1.
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Synonym: α,α-Trehalose; D-(+)-Trehalose dihydrate
Application: An osmolyte, chemical chaperone, and inducer of autophagy
CAS Number: 6138-23-4
Purity: ≥99%
Molecular Weight: 378.33
Molecular Formula: C12H22O112H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Trehalose dihydrate, is an osmolyte, a chemical chaperone and inducer of autophagy, that has been reported to protect cells against numerous environmental stresses. This compound contains many properties that allow it to stabilize partially unfolded protein molecules and inhibit protein aggregation. These properties include a low chemical reactivity, high glass transition temperature, existence of numerous polymorphs, nonreducing nature, and high affinity for water molecules. Additionally, Trehalose has been noted to bind to expanded polyglutamines and stabilize partially unfolded polyglutamine-containing proteins.

Appearance :
Powder
Physical State :
Solid
Derived From :
Saccharomyces cerevisiae
Solubility :
Soluble in water (689 mg/ml at 20° C), and hot alcohol. Insoluble in ether.
Storage :
Store at room temperature
Melting Point :
97-99° C
Optical Activity :
α20D +181.5°±3.5°, c = 7 in water
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
181978
Merck Index :
14: 9580
MDL Number :
MFCD00071594
EC Number :
202-739-6
Beilstein Registry :
5322018
SMILES :
C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)O)O.O.O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Jamil et al Jamil et al. (PubMed ID 24462846) used Trehalose dihydrate as a stabilizer to study the thermostabilities of lyophilized live-attenuated mumps vaccine formulations. -SCBT Publication Review
Date published: 2015-01-20
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