Trehalose dihydrate, is an osmolyte, a chemical chaperone and inducer of autophagy, that has been reported to protect cells against numerous environmental stresses. This compound contains many properties that allow it to stabilize partially unfolded protein molecules and inhibit protein aggregation. These properties include a low chemical reactivity, high glass transition temperature, existence of numerous polymorphs, nonreducing nature, and high affinity for water molecules. Additionally, Trehalose has been noted to bind to expanded polyglutamines and stabilize partially unfolded polyglutamine-containing proteins.
Soluble in water (689 mg/ml at 20° C), and hot alcohol. Insoluble in ether.
Store at room temperature
α20D +181.5°±3.5°, c = 7 in water
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Jamil et alJamil et al. (PubMed ID 24462846) used Trehalose dihydrate as a stabilizer to study the thermostabilities of lyophilized live-attenuated mumps vaccine formulations. -SCBT Publication Review
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