Trapoxin A

Trapoxin A  (CAS 133155-89-2)

Trapoxin A, CAS 133155-89-2 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_15, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_253730, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 115ms
  • REVIEWS, PRODUCT
Synonym: RF 1023A
Application: A cyclotetrapeptide HDAC inhibitor
CAS Number: 133155-89-2
Purity: ≥98%
Molecular Weight: 602.72
Molecular Formula: C34H42N4O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Trapoxin A is a cyclotetrapeptide and an HDAC (histone deacetylase) inhibitor. Trapoxin increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin irreversibly inhibits HDAC activity in crude cell lysates and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.


References

1. Fang, J.Y., and Lu, Y.Y., Effects of histone acetylation and DNA methylation on p21 (WAF1) regulation. World J. Gastroenterol. 8, 400-405, (2002) 2. Yoshida, M., et al., Trichostatin A and Trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays 17, 423-430, (1995) 3. Vigushin, D.M., and Coombes, R.C., Histone deacetylase inhibitors in cancer treatment. Anti-Cancer Drugs 13, 1-13, (2002)

Physical State :
Solid
Solubility :
DMSO: may be further diluted 20 fold in H2O soluble: chloroform: soluble: methanol: soluble
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
121875
SMILES :
C1CCN2[C@H](C1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C2=O)CC3=CC=CC=C3)CC4=CC=CC=C4)CCCCCC(=O)[C@@H]5CO5

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 95ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from An increase in Ac An increase in Ac-Histone H3 expression observed by WB in HeLa cells post treatment with Trapoxin A. -SCBT QC
Date published: 2015-03-16
  • y_2019, m_9, d_15, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_253730, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.