Tranylcypromine is an irreversible inhibitor of monoamine oxidase (MAO), and an inhibitor of CYP2A6 (Ki= 0.08 μM) and histone demethylase BHC110/LSD1. The inhibitor targets MAO-A and MAO-B and has been used as a chemical scaffold to design new demethylase inhibitors. Studies suggest that tranylcypromine can increase both brain trace amines and GABA(B)-receptors, and regulate phospholipid metabolism. Tranylcypromine has been shown to increase Histone H3 lysine 4 (H3K4) methylation and transcriptional derepression of Egr1 and Oct4 in P19 embryonal carcinoma cells (sc-24760). Studies indicate that it is an effective inhibitor of histone demethylation and can antagonize the effects of phenylephrine.
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See how others have used Tranylcypromine. Click on the entry to view the PubMed entry .
PMID: # 25103574 Liu, D. et al. 2014. Genes Nutr. 9: 422.
PMID: # 22534778 Piao, JY. et al. 2012. Analyst. 137: 2669-73.
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