trans Resveratrol 3-O-β-D-Glucuronide (CAS 387372-17-0)
See product citations (4)
QUICK LINKS
trans Resveratrol 3-O-β-D-glucuronide is a glucuronidated metabolite of trans-resveratrol, a naturally occurring polyphenolic compound found in various plants, including grapes, berries, and peanuts. This metabolite is formed through the enzymatic action of glucuronosyltransferases, which catalyze the addition of glucuronic acid to trans-resveratrol, enhancing its solubility and facilitating its excretion. In research applications, trans Resveratrol 3-O-β-D-glucuronide is of interest for studying the metabolism and bioavailability of resveratrol and its implications for cellular antioxidant defense mechanisms. Its formation and subsequent accumulation in biological systems are indicative of the phase II metabolic processing of resveratrol, highlighting the body′s capability to modify and eliminate bioactive compounds. This metabolite serves as a marker for understanding the pharmacokinetics and distribution pathways of resveratrol in organisms, shedding light on the compound′s biological effects and its potential roles in modulating oxidative stress and cellular signaling pathways.
trans Resveratrol 3-O-β-D-Glucuronide (CAS 387372-17-0) References
- A concise synthesis of the 3-O-beta-D- and 4'-O-beta-D-glucuronide conjugates of trans-resveratrol. | Learmonth, DA. 2003. Bioconjug Chem. 14: 262-7. PMID: 12526717
- Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. | Wenzel, E., et al. 2005. Mol Nutr Food Res. 49: 482-94. PMID: 15779067
- Ultra high performance liquid chromatography-quadrupole-time of flight analysis for the identification and the determination of resveratrol and its metabolites in mouse plasma. | Menet, MC., et al. 2013. Anal Chim Acta. 761: 128-36. PMID: 23312323
- Semi-preparative isolation of dihydroresveratrol-3-O-β-d-glucuronide and four resveratrol conjugates from human urine after oral intake of a resveratrol-containing dietary supplement. | Radko, Y., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 930: 54-61. PMID: 23727867
- The stilbenes resveratrol, pterostilbene and piceid affect growth and stress resistance in mammalian cells via a mechanism requiring estrogen receptor beta and the induction of Mn-superoxide dismutase. | Robb, EL. and Stuart, JA. 2014. Phytochemistry. 98: 164-73. PMID: 24361291
- Effect of resveratrol on experimental non-alcoholic steatohepatitis. | Heebøll, S., et al. 2015. Pharmacol Res. 95-96: 34-41. PMID: 25814186
- Determination of trans-resveratrol and its metabolites in rat serum using liquid chromatography with high-resolution time of flight mass spectrometry. | Rousova, J., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1039: 35-43. PMID: 27818239
- A simple LC-MS/MS method for the simultaneous quantification of resveratrol and its major phase II metabolites: Assessment of their urinary and biliary excretions in rats. | Qiu, Z., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1048: 85-93. PMID: 28226267
- A simple LC-MS/MS method facilitated by salting-out assisted liquid-liquid extraction to simultaneously determine trans-resveratrol and its glucuronide and sulfate conjugates in rat plasma and its application to pharmacokinetic assay. | Qiu, Z., et al. 2017. Biomed Chromatogr. 31: PMID: 28475242
- Role of sulfotransferases in resveratrol metabolism in human adipocytes. | Gheldof, N., et al. 2017. Mol Nutr Food Res. 61: PMID: 28523759
- Quantification of trans-resveratrol and its metabolites in human plasma using ultra-high performance liquid chromatography tandem quadrupole-orbitrap mass spectrometry. | Svilar, L., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1104: 119-129. PMID: 30453129
- Comparative toxicokinetics of Trans-resveratrol and its major metabolites in Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration. | Mutlu, E., et al. 2020. Toxicol Appl Pharmacol. 394: 114962. PMID: 32205187
- Resveratrol Metabolites Are Able to Reduce Steatosis in Cultured Hepatocytes. | Trepiana, J., et al. 2020. Pharmaceuticals (Basel). 13: PMID: 33008087
- Measurement of Saccharin and trans-Resveratrol Metabolites in Urine as Adherence Markers for Small Quantity Lipid-Based Nutrient Supplement Consumption. | Weinborn, V., et al. 2021. J Agric Food Chem. 69: 1107-1114. PMID: 33439009
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trans Resveratrol 3-O-β-D-Glucuronide, 1 mg | sc-213069 | 1 mg | $533.00 |