trans-HR22C16An inhibitor of mitosis not interacting with tubulin

trans-HR22C16 (CAS 462630-41-7)

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Application: An inhibitor of mitosis not interacting with tubulin
CAS Number: 462630-41-7
Purity: ≥95%
Molecular Weight: 389.5
Molecular Formula: C23H23N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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trans-HR22C16 is a cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=800nM) by binding to the mitotic kinesin Eg5.


References

1. Hotha, S., et al. 2003. Angew. Chem. Int. Ed. Engl. 42: 2379-2382. PMID: 12783501

Physical State :
Solid
Solubility :
Soluble in DMSO (10mg/ml).
Storage :
Store at -20° C
Melting Point :
278.37° C (Predicted)
Boiling Point :
601.99° C at 760 mmHg (Predicted)
Density :
1.41 g/cm3 (Predicted)
Refractive Index :
n20D 1.73 (Predicted)
IC50 :
Eg5: IC50 = 0.8 µM (human); HeLa: IC50 = 8.6 µM (human)
pK Values :
pKa: 9.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10960093
MDL Number :
MFCD08702686
SMILES :
CCCCN1C(=O)C2CC3=C(C(N2C1=O)C4=CC(=CC=C4)O)NC5=CC=CC=C35

Download SDS (MSDS)

Certificate of Analysis

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