MF: C4H6O3 MW: 102.09 A compound that binds to the GHB receptor with higher affinity than GHB.
GABA Metabolism and Transport
trans-4-Hydroxycrotonic acid (CAS 24587-49-3)
(E)-4-Hydroxycrotonic Acid; trans-γ-Hydroxycrotonic Acid
C 4H 6O 3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. Available in US only. *
Certificate of Analysis for lot specific data (including water content).
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trans-4-Hydroxycrotonic acid binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself. It may be an endogenous ligand. References
1. Vayer, P., et al. 1985. Biochem Pharmacol. 34: 2401-2404.
2. Bourguignon, J.J., et al. 1993. J. Med. Chem. 31: 893-897. 3. Hechler, V., et al. 1993. J. Pharmacol. Exp. Ther. 264: 1406-1414.
Soluble in DMSO (100 mM).
Desiccate at 4° C
45.99° C (Predicted)
~338.75° C at 760 mmHg (Predicted)
20 D 1.50 (Predicted)
γ-hydroxybutyrate receptor: IC
50 = 3.5 nM (rat)
Displacement of [3H]NCS-382 from GABAB receptor in rat brain homogenate: K
i= 1 µM (rat)
a: 4.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. Available in US only.
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