trans-4-Hydroxycrotonic acid CAS: 24587-49-3
MF: C4H6O3
MW: 102.09
A compound that binds to the GHB receptor with higher affinity than GHB.

trans-4-Hydroxycrotonic acid (CAS 24587-49-3)

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Alternate Names: (E)-4-Hydroxycrotonic Acid; trans-γ-Hydroxycrotonic Acid
Application: trans-4-Hydroxycrotonic acid is a compound that binds to the GHB receptor with higher affinity than GHB
CAS Number: 24587-49-3
Purity: >99%
Molecular Weight: 102.09
Molecular Formula: C4H6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).

trans-4-Hydroxycrotonic acid binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself. It may be an endogenous ligand.


References

1. Vayer, P., et al. 1985. Biochem Pharmacol. 34: 2401-2404.
2. Bourguignon, J.J., et al. 1993. J. Med. Chem. 31: 893-897.
3. Hechler, V., et al. 1993. J. Pharmacol. Exp. Ther. 264: 1406-1414.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Desiccate at 4° C
Melting Point :
45.99° C (Predicted)
Boiling Point :
~338.75° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
γ-hydroxybutyrate receptor: IC50 = 3.5 nM (rat)
Ki Data :
Displacement of [3H]NCS-382 from GABAB receptor in rat brain homogenate: Ki= 1 µM (rat)
pK Values :
pKa: 4.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
PubChem CID :
MDL Number :
MFCD00673880
SMILES :
C(/C=C/C(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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