Tracazolate hydrochloride CAS: 1135210-68-2
MF: C16H24N4O2•HCl
MW: 340.85
A modulator of GABAA receptors.

Tracazolate hydrochloride (CAS 1135210-68-2)

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Alternate Names: ICI 136753
Application: Tracazolate hydrochloride is a modulator of GABAA receptors
CAS Number: 1135210-68-2
Purity: ≥99%
Molecular Weight: 340.85
Molecular Formula: C16H24N4O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Tracazolate hydrochloride is a subtype selective GABAA allosteric receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Tracazolate hydrochloride enhances native GABAA receptor function.


References

1. Meiners, B.A. and Salama, A.I. 1982. Eur. J. Pharmacol. 78: 315-322.
2. Patel, J.B. and Malick, J.B. 1982. Eur. J. Pharmacol. 78: 323-333.
3. Thompson, S.A., et al. 2002. Mol. Pharmacol. 61: 861-869.

Physical State :
Solid
Solubility :
Soluble in 1eq. HCl (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
EC Number :
255-214-9
SMILES :
CCCCNC1=C2C=NN(C2=NC(=C1C(=O)OCC)C)CC.Cl

Download SDS (MSDS)

Certificate of Analysis

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PMID: # 31180326  Elife.

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