Toremifene is a chlorinated tamoxifen analogue which competes with estradiol for estrogen receptors and has growth inhibitory effects on MCF-7 breast cancer cells. Toremifene causes growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to undergo apoptosis and by inhibiting other cells from entering mitosis.
1. Wärri, A.M. et al. 1993. J. Natl. Cancer Inst. 85(17): 1412-1418. PMID: 8350365 2. Mäenpää, J.U. and Ala-Fossi, S.L. 1997. Drugs Aging. 11(4): 261-270. PMID: 9342556 3. Johansen, L.M. et al. 2013. Sci Transl Med. 5(190): 190ra79. PMID: 23785035
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Johansen et alJohansen et al. (PubMed ID 23785035) found that Toremifene inhibited infection by the Ebola virus by interfering with the triggering of fusion. -SCBT Publication Review
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