ToremifeneAn analog of chlorinated tamoxifen and an antiproliferative agent

Toremifene (CAS 89778-26-7)

Toremifene | CAS 89778-26-7 is rated 5.0 out of 5 by 1.
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Application: An analog of chlorinated tamoxifen and an antiproliferative agent
CAS Number: 89778-26-7
Purity: ≥98%
Molecular Weight: 405.96
Molecular Formula: C26H28ClNO
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Toremifene is a chlorinated tamoxifen analogue which competes with estradiol for estrogen receptors and has growth inhibitory effects on MCF-7 breast cancer cells. Toremifene causes growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to undergo apoptosis and by inhibiting other cells from entering mitosis.


References

1. Wärri, A.M. et al. 1993. J. Natl. Cancer Inst. 85(17): 1412-1418. PMID: 8350365
2. Mäenpää, J.U. and Ala-Fossi, S.L. 1997. Drugs Aging. 11(4): 261-270. PMID: 9342556
3. Johansen, L.M. et al. 2013. Sci Transl Med. 5(190): 190ra79. PMID: 23785035

Physical State :
Solid
Solubility :
Soluble in water (partly), DMSO, and methanol.
Storage :
Store at room temperature
Melting Point :
108-110° C
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Perilipin: IC50 = 1.14 µM (human); Streptokinase A: EC5050 = 4.95 µM (Streptococcus pyogenes serotype M1); Streptococcus sp. 'group A': EC5050 = 5.82 µM; Streptococcus: EC5050 = 8.17 µM
Ki Data :
SR-6: Ki= 4.13 µM (human)
pK Values :
pKb: 8.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3005573
Merck Index :
14: 9550
MDL Number :
MFCD00801070
SMILES :
CN(C)CCOC1=CC=C(C=C1)C(=C(CCCl)C2=CC=CC=C2)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

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Certificate of Analysis

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Toremifene  Product Citations

See how others have used Toremifene. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27693991  Görgens, C. et al. 2016. Journal of pharmaceutical and biomedical analysis. 131: 482-496.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Johansen et al Johansen et al. (PubMed ID 23785035) found that Toremifene inhibited infection by the Ebola virus by interfering with the triggering of fusion. -SCBT Publication Review
Date published: 2015-07-08
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