Topotecan HydrochlorideA water-soluble inhibitor of DNA Topo I

Topotecan Hydrochloride (CAS 119413-54-6)

Topotecan Hydrochloride | CAS 119413-54-6 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_10, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204919, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 89ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Application: A water-soluble inhibitor of DNA Topo I
CAS Number: 119413-54-6
Purity: ≥99%
Molecular Weight: 457.9
Molecular Formula: C23H23N3O5 HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Topotecan Hydrochloride is the water-soluble hydrochloride salt preparation of Topotecan, a potent inhibitor of topoisomerase 1 (Topo I), producing proapoptotic and antiproliferative effects. Topotecan is a semisynthetic derivative of the natural product alkaloid camptothecin (sc-200871). Topotecan is described to stabilize topoisomerase I/DNA cleavable complexes and promote rapid apoptotic cell death in radiation-resistant human B-lineage acute lymphoblastic leukemia cells.


References

1. Kingsbury, W.D., et al. 1991. J. Med. Chem. 34: 98-107. PMID: 1846923
2. Uckun, F.M., et al. 1995. Blood. 85: 2817-2828. PMID: 7742543
3. Arun, B., et al. 2001. Expert Opin Pharmacother. 2: 491-505. PMID: 11336601

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol, water (92 mg/ml at 25° C), DMSO (92 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and 1: 1 solution of DMSO: PBS (pH 7.2, ~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
213-218° C
Boiling Point :
782.9° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.73 (Predicted)
Optical Activity :
α25/D +94°, c = 0.5 in water
IC50 :
HCT-8: IC50 = 1.5 nM (human); MCF7: IC50 = 1.8 nM (human); DU-145 Luc cells: IC50 = 2 nM; A549: IC50 = 3.2 nM (human); SW-620: IC50 = 3.2 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UQ0491400
PubChem CID :
60699
Merck Index :
14: 9548
MDL Number :
MFCD00866235
SMILES :
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-204919, is provided as a light yellow crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-26
  • y_2019, m_11, d_10, h_13CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_204919, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 92ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Darby RA; et al Darby RA; et al. (PubMed ID: 26351135) determined that Topotecan Hydrochloride in combination with PIM1 inhibitors increased the cytotoxic effect in ABCG2-expressing cancer cells. -SCBT Publication Review
Date published: 2015-06-30
  • y_2019, m_11, d_10, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204919, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 4ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.