Tomoxetine hydrochlorideA selective SLC6A2 inhibitor

Tomoxetine hydrochloride (CAS 82248-59-7)

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Application: A selective SLC6A2 inhibitor
CAS Number: 82248-59-7
Purity: ≥99%
Molecular Weight: 291.82
Molecular Formula: C17H21NO•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tomoxetine hydrochloride (Atomoxetine, LY 139603) is a competitive and specific inhibitor of SLC6A2 while demonstrating weak ST and DAT inhibition as studied in synaptosomes of rat hypothalamus. Additionally, studies indicate that this (−) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride; sc-211408). In the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain. Tomoxetine hydrochloride is an inhibitor of NMDA.


References

1. Wong, D.T., et al. 1995. Life Sci. 57: 411-441. PMID: 7623609
2. Beck, S.G., et al. 1997. J. Pharmacol. Exp. Ther. 281: 115-122. PMID: 9103487
3. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006

Physical State :
Solid
Solubility :
Soluble to 50 mM in Water
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
54840
MDL Number :
MFCD06410992
SMILES :
Cl.CNCCC(OC1=C(C)C=CC=C1)C1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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