TolvaptanCAS: 150683-30-0
MF: C26H25ClN2O3
MW: 448.94
A selective vasopressin receptor 2 antagonist.

Tolvaptan (CAS 150683-30-0)

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Synonym: Samsca; OPC 41061
Application: A selective vasopressin receptor 2 antagonist
CAS Number: 150683-30-0
Molecular Weight: 448.94
Molecular Formula: C26H25ClN2O3
* Refer to Certificate of Analysis for lot specific data (including water content).

Tolvaptan is a selective, competitive vasopressin receptor 2 antagonist with an IC50 of 1.28µM for the inhibition of AVP-induced platelet aggregation. Tolvaptan is used to treat hyponatremia associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone. Tolvaptan is also in fast-track clinical trials for polycystic kidney disease. Treatment with Tolvaptan causes rapid and sustained body weight reductions concurrent with increases in urine output, improves and/or normalizes serum sodium in hyponatremic patients, reduces signs and symptoms of congestion and increases thirst. However, Tolvaptan has not been shown to decrease heart failure re-hospitalization or mortality. As an adjunct to standard therapy, Tolvaptan is unique in that it is virtually the only novel agent tested in patients hospitalized for acute heart failure syndrome to reach its primary end point for short-term efficacy without causing deleterious side effects.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (90 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), and ethanol (6 mg/mL at 25 °C).
Storage :
Store at 4° C
Melting Point :
225-230° C
Boiling Point :
~594.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
AVP Receptor V2: IC50 = 1.28 µM
Ki Data :
AVP Receptor V2: Ki= 0.43 nM (human)
pK Values :
pKa: 13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
216237
MDL Number :
MFCD09838782
SMILES :
CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C

Download SDS (MSDS)

Certificate of Analysis

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Onde posso comprar na Europa ou nos EUA?

Asked by: Luciana bame
Thank you for your question. We can sell our products directly in both the U.S.A and Europe. If you are located in Brazil, please contact our U.S. headquarters using the contact information below. Alternatively, please contact one of our authorized distributors in Brazil. https://www.scbt.com/scbt/customer-care/contact-us https://www.scbt.com/scbt/resources/distributors
Answered by: Technical Support
Date published: 2018-06-13
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