Toll-Like Receptor 7 Ligand IIA TLR7 agonist

Toll-Like Receptor 7 Ligand II (CAS 226907-52-4)

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Synonym: TLR7 Ligand II; 9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine; 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
Application: A TLR7 agonist
CAS Number: 226907-52-4
Molecular Weight: 315.33
Molecular Formula: C15H17N5O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Toll-Like Receptor 7 Ligand II is a cell-permeable hydroxyadenine compound which acts as a potent and highly specific toll-like receptor 7 (TLR7) agonist, without any detectable activity towards TLR2/3/5/8/9. It is shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures in vitro .


References

1. Kurimoto, Ayumu., et al., 2004. Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities. Bioorganic & medicinal chemistry. 12(5): 1091-9. PMID: 14980621
2. Lee, Jongdae., et al., 2006. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proceedings of the National Academy of Sciences of the United States of America. 103(6): 1828-33. PMID: 16446426
3. Jin, Guangyi., et al., 2006. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. Bioorganic & medicinal chemistry letters. 16(17): 4559-63. PMID: 16784848

Physical State :
Solid
Solubility :
Soluble in DMSO or Methanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10018576
SMILES :
COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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