Toll-Like Receptor 7 Ligand II is a cell-permeable hydroxyadenine compound which acts as a potent and highly specific toll-like receptor 7 (TLR7) agonist, without any detectable activity towards TLR2/3/5/8/9. It is shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures in vitro .
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2. Lee, Jongdae., et al., 2006. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proceedings of the National Academy of Sciences of the United States of America. 103(6): 1828-33. PMID: 16446426
3. Jin, Guangyi., et al., 2006. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. Bioorganic & medicinal chemistry letters. 16(17): 4559-63. PMID: 16784848
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